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  1. Article

    Open Access

    Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

    ABT-737 is a pharmacological inhibitor of the anti-apoptotic activity of B-cell lymphoma-extra large (Bcl-xL) protein; it promotes apoptosis of cancer cells by occupying the BH3-binding pocket. We have shown p...

    Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan… in Cell Death & Differentiation (2017)

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    Article

    A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

    Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of vesicles from reserve pools within the synapse, which is...

    Hongmei Li, Kambiz N. Alavian, Emma Lazrove, Nabil Mehta… in Nature Cell Biology (2013)