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  1. Article

    Open Access

    Parkinson’s disease protein DJ-1 regulates ATP synthase protein components to increase neuronal process outgrowth

    Familial Parkinson’s disease (PD) protein DJ-1 mutations are linked to early onset PD. We have found that DJ-1 binds directly to the F1FO ATP synthase β subunit. DJ-1’s interaction with the β subunit decreased mi...

    Rongmin Chen, Han-A Park, Nelli Mnatsakanyan, Yulong Niu… in Cell Death & Disease (2019)

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  2. Article

    Open Access

    Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

    ABT-737 is a pharmacological inhibitor of the anti-apoptotic activity of B-cell lymphoma-extra large (Bcl-xL) protein; it promotes apoptosis of cancer cells by occupying the BH3-binding pocket. We have shown p...

    Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan… in Cell Death & Differentiation (2017)

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  3. Article

    Open Access

    The lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed

    Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors ...

    Kambiz N Alavian, Sharmin Jeddi, Sahar I Naghipour… in Journal of Biomedical Science (2014)

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  4. No Access

    Article

    A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis

    Following exocytosis, the rate of recovery of neurotransmitter release is determined by vesicle retrieval from the plasma membrane and by recruitment of vesicles from reserve pools within the synapse, which is...

    Hongmei Li, Kambiz N. Alavian, Emma Lazrove, Nabil Mehta… in Nature Cell Biology (2013)

  5. No Access

    Article

    Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

    Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of t...

    Hyo Jung Kang, Bhavya Voleti, Tibor Hajszan, Grazyna Rajkowska… in Nature Medicine (2012)

  6. No Access

    Article

    A negative regulator of MAP kinase causes depressive behavior

    Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated ...

    Vanja Duric, Mounira Banasr, Pawel Licznerski, Heath D Schmidt… in Nature Medicine (2010)

  7. No Access

    Article

    Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

    Sensory experience is necessary for normal cortical development. This has been shown by sensory deprivation and pharmacological perturbation of the cortex. Because these manipulations affect the cortical netwo...

    Shoji Komai, Pawel Licznerski, Ali Cetin, Jack Waters, Winfried Denk… in Nature Neuroscience (2006)