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  1. No Access

    Article

    Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

    Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of t...

    Hyo Jung Kang, Bhavya Voleti, Tibor Hajszan, Grazyna Rajkowska… in Nature Medicine (2012)

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    Article

    A negative regulator of MAP kinase causes depressive behavior

    Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated ...

    Vanja Duric, Mounira Banasr, Pawel Licznerski, Heath D Schmidt… in Nature Medicine (2010)

  3. No Access

    Article

    Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

    Sensory experience is necessary for normal cortical development. This has been shown by sensory deprivation and pharmacological perturbation of the cortex. Because these manipulations affect the cortical netwo...

    Shoji Komai, Pawel Licznerski, Ali Cetin, Jack Waters, Winfried Denk… in Nature Neuroscience (2006)