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  1. No Access

    Article

    Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

    Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of t...

    Hyo Jung Kang, Bhavya Voleti, Tibor Hajszan, Grazyna Rajkowska… in Nature Medicine (2012)

  2. No Access

    Article

    A negative regulator of MAP kinase causes depressive behavior

    Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated ...

    Vanja Duric, Mounira Banasr, Pawel Licznerski, Heath D Schmidt… in Nature Medicine (2010)