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Article
Open AccessThe lifelong maintenance of mesencephalic dopaminergic neurons by Nurr1 and engrailed
Specific vulnerability and degeneration of the dopaminergic neurons in the substantia nigra pars compacta of the midbrain is the pathological hallmark of Parkinson’s disease. A number of transcription factors ...
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Article
Decreased expression of synapse-related genes and loss of synapses in major depressive disorder
Ronald Duman and colleagues report that synapse number is reduced in subjects with major depressive disorder. This is associated with decreased expression of synapse-related genes and increased expression of t...
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Article
A negative regulator of MAP kinase causes depressive behavior
Gene expression changes that occur in the brains of people with depression could lead to the development of new therapies. Now, Ronald Duman and his colleagues report that the phosphatase Mkp-1 is upregulated ...
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Article
Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development
Sensory experience is necessary for normal cortical development. This has been shown by sensory deprivation and pharmacological perturbation of the cortex. Because these manipulations affect the cortical netwo...