3 Result(s)
within
Pavlina Zatloukalova
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Article
Open AccessResistance mechanisms to inhibitors of p53-MDM2 interactions in cancer therapy: can we overcome them?
Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the p53-binding domain of MDM2...
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Article
Open AccessThe MDM2 ligand Nutlin-3 differentially alters expression of the immune blockade receptors PD-L1 and CD276
The links between the p53/MDM2 pathway and the expression of pro-oncogenic immune inhibitory receptors in tumor cells are undefined. In this report, we evaluate whether there is p53 and/or MDM2 dependence in t...
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Article
Integration of genetic and physical maps of the chickpea (Cicer arietinum L.) genome using flow-sorted chromosomes
Cultivated chickpea is the third most important legume after field bean and garden pea worldwide. Despite considerable breeding towards improved yield and resistance to biotic and abiotic stresses, the product...
