3 Result(s)
within
Paula Martínez-Cristóbal
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Article
Open AccessRational optimization of a transcription factor activation domain inhibitor
Transcription factors are among the most attractive therapeutic targets but are considered largely ‘undruggable’ in part due to the intrinsically disordered nature of their activation domains. Here we show tha...
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Article
Open AccessAuthor Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessHsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to be...
