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Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases

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  1. Article

    Open Access

    Multiomics in primary and metastatic breast tumors from the AURORA US network finds microenvironment and epigenetic drivers of metastasis

    The AURORA US Metastasis Project was established with the goal to identify molecular features associated with metastasis. We assayed 55 females with metastatic breast cancer (51 primary cancers and 102 metasta...

    Susana Garcia-Recio, Toshinori Hinoue, Gregory L. Wheeler… in Nature Cancer (2023)

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  2. Article

    Open Access

    Multi-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes

    Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (...

    Brian D. Lehmann, Antonio Colaprico, Tiago C. Silva, Jianjiao Chen… in Nature Communications (2021)

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  3. Article

    Open Access

    PIK3CA and MAP3K1 alterations imply luminal A status and are associated with clinical benefit from pan-PI3K inhibitor buparlisib and letrozole in ER+ metastatic breast cancer

    Clinical trials have demonstrated the efficacy of combining phosphoinositide 3-kinase (PI3K) inhibitors with endocrine therapies in hormone therapy-refractory breast cancer. However, biomarkers of PI3K pathway...

    Mellissa J. Nixon, Luigi Formisano, Ingrid A. Mayer… in npj Breast Cancer (2019)

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  4. Article

    Open Access

    DNA methyltransferase inhibition upregulates MHC-I to potentiate cytotoxic T lymphocyte responses in breast cancer

    Potentiating anti-tumor immunity by inducing tumor inflammation and T cell-mediated responses are a promising area of cancer therapy. Immunomodulatory agents that promote these effects function via a wide vari...

    Na Luo, Mellissa J. Nixon, Paula I. Gonzalez-Ericsson… in Nature Communications (2018)

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