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Article
Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer
Co-occurrent KRAS and TP53 mutations define a majority of patients with pancreatic ductal adenocarcinoma (PDAC) and define its pro-metastatic proclivity. Here, we demonstrate that KRAS-TP53 co-alteration is assoc...
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Article
Open AccessMulti-omics analysis identifies therapeutic vulnerabilities in triple-negative breast cancer subtypes
Triple-negative breast cancer (TNBC) is a collection of biologically diverse cancers characterized by distinct transcriptional patterns, biology, and immune composition. TNBCs subtypes include two basal-like (...
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Article
Open AccessInterpreting pathways to discover cancer driver genes with Moonlight
Cancer driver gene alterations influence cancer development, occurring in oncogenes, tumor suppressors, and dual role genes. Discovering dual role cancer genes is difficult because of their elusive context-dep...
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Article
Open AccessPolycomb complexes associate with enhancers and promote oncogenic transcriptional programs in cancer through multiple mechanisms
Polycomb repressive complex 1 (PRC1) plays essential roles in cell fate decisions and development. However, its role in cancer is less well understood. Here, we show that RNF2, encoding RING1B, and canonical PRC1...
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Article
Open AccessIntegration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis
Modern high-throughput genomic technologies represent a comprehensive hallmark of molecular changes in pan-cancer studies. Although different cancer gene signatures have been revealed, the mechanism of tumouri...
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Article
Open AccessHow interacting pathways are regulated by miRNAs in breast cancer subtypes
An important challenge in cancer biology is to understand the complex aspects of the disease. It is increasingly evident that genes are not isolated from each other and the comprehension of how different genes...
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Chapter and Conference Paper
An Approach to Identify miRNA Associated with Cancer Altered Pathways
MicroRNAs play an important role in the regulation of gene expression by binding mRNA targets causing their degradation or blocking their translation. Several genes has been found to be implicated as miRNA tar...
