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Article
Open AccessLow thiamine status in adults following low-carbohydrate / ketogenic diets: a cross-sectional comparative study of micronutrient intake and status
Low-carbohydrate diets (LCD) are popular for weight loss but lack evidence about micronutrient sufficiency in real-life use. This study assessed the intake and biochemical status of selected micronutrients in ...
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Article
Open AccessSocioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization
The associations between deprivation and illness trajectory after hospitalisation for coronavirus disease-19 (COVID-19) are uncertain.
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Article
Open AccessTwenty-four-hour ambulatory, but not clinic blood pressure associates with leptin in young adults with overweight or obesity: The African-PREDICT study
Hypertension and obesity are known pro-inflammatory conditions, and limited studies explored various blood pressure modalities and inflammatory markers in young adults with overweight or obesity (OW/OB). We as...
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Article
Open AccessThe metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signature of overweight and type 2 diabetes. However, the extent to which these metabolomic pa...
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Article
Open AccessUsing trials of caloric restriction and bariatric surgery to explore the effects of body mass index on the circulating proteome
Thousands of proteins circulate in the bloodstream; identifying those which associate with weight and intervention-induced weight loss may help explain mechanisms of diseases associated with adiposity. We aime...
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Article
Open AccessDose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
Most studies investigating the association between physical activity (PA) and the risk of type 2 diabetes are derived from self-reported questionnaires, with limited evidence using device-based measurements. T...
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Article
Body composition and lung cancer-associated cachexia in TRACERx
Cancer-associated cachexia (CAC) is a major contributor to morbidity and mortality in individuals with non-small cell lung cancer. Key features of CAC include alterations in body composition and body weight. H...
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Article
Open AccessChanges in women’s physical function in mid-life by reproductive age and hormones: a longitudinal study
Whether women’s physical function in mid-life is related to their reproductive age is not known. The objectives of this study were to examine and compare changes in physical function in women by reproductive a...
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Article
Open AccessCardiovascular health in the menopause transition: a longitudinal study of up to 3892 women with up to four repeated measures of risk factors
Women experience adverse changes in cardiovascular health in mid-life; whether the menopausal transition influences these remains strongly debated. The aim of this study was to examine associations of reproduc...
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Open AccessAuthor Correction: Genetic analysis of over half a million people characterises C-reactive protein loci
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Article
Open AccessA multisystem, cardio-renal investigation of post-COVID-19 illness
The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been...
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Article
Open AccessEthnic differences in cardiovascular risk: examining differential exposure and susceptibility to risk factors
Ethnic differences in cardiovascular disease (CVD) risk have been known for decades, but a systematic exploration of how exposure and susceptibility to risk factors may contribute is lacking. This study aimed ...
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Article
Open AccessGenetic analysis of over half a million people characterises C-reactive protein loci
Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of systemic inflammation, in UK Bio...
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Article
Open AccessMuscle protein synthesis and muscle/metabolic responses to resistance exercise training in South Asian and White European men
The aims of the current study, therefore, were to compare (1) free-living MPS and (2) muscle and metabolic adaptations to resistance exercise in South Asian and white European adults. Eighteen South Asian and ...
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Article
Open AccessDose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank
Previous cohort studies have investigated the relationship between self-reported physical activity (PA) and dementia. Evidence from objective device-measured PA data is lacking. This study aimed to explore the...
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Article
Open AccessInterrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function
Arteriovenous fistula (AVF) is the preferred type of vascular access for maintenance haemodialysis but it may contribute to maladaptive cardiovascular remodelling. We studied the effect of AVF creation on card...
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Article
Open AccessAre people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants
People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. Thi...
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Article
Open AccessComparison of two different frailty measurements and risk of hospitalisation or death from COVID-19: findings from UK Biobank
Frailty has been associated with worse prognosis following COVID-19 infection. While several studies have reported the association between frailty and COVID-19 mortality or length of hospital stay, there have ...
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Article
Open AccessTissue sodium excess is not hypertonic and reflects extracellular volume expansion
Our understanding of Na+ homeostasis has recently been reshaped by the notion of skin as a depot for Na+ accumulation in multiple cardiovascular diseases and risk factors. The proposed water-independent nature of...
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Article
Author Correction: Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
