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  1. Article

    Open Access

    Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma

    MAPK7/ERK5 (extracellular-signal-regulated kinase 5) functions within a canonical three-tiered MAPK (mitogen activated protein kinase) signaling cascade comprising MEK (MAPK/ERK kinase) 5, MEKK(MEK kinase) 2/3...

    Paul R. Gavine, Mei Wang, Dehua Yu, Eva Hu, Chunlei Huang, Jenny **a… in BMC Cancer (2015)

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  2. Article

    Open Access

    Trastuzumab anti-tumor efficacy in patient-derived esophageal squamous cell carcinoma xenograft (PDECX) mouse models

    Trastuzumab is currently approved for the clinical treatment of breast and gastric cancer patients with HER-2 positive tumors, but not yet for the treatment of esophageal carcinoma patients, whose tumors typic...

    **anhua Wu, **gchuan Zhang, Ruheng Zhen, **g Lv… in Journal of Translational Medicine (2012)

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    Article

    Protein stabilization: a common consequence of mutations in independently derived v-Myc alleles

    Myc is overexpressed in many cancers as a result of gene rearrangement or amplification, but coding sequence changes which cluster in the N-terminal transactivation domain also appear to play a role in tumour ...

    Paul R Gavine, James C Neil, Dorothy H Crouch in Oncogene (1999)