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Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication

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  1. Article

    Open Access

    Modified One Anastomosis Gastric Bypass Following Sleeve Gastrectomy for Severe Reflux and Delayed Gastric Emptying: A Prospective Trial with Clinical and Physiological Outcome Measures

    Gastro-esophageal reflux (GORD) following sleeve gastrectomy (SG) is a central challenge, and precise indications for revisional surgery or the physiology have not been precisely defined. We aimed to determine...

    Anagi C. Wickremasinghe, Yit J. Leang, Yazmin Johari, Cheryl Laurie in Obesity Surgery (2024)

  2. Article

    Open Access

    Emerging multi-port soft tissue robotic systems: a systematic review of clinical outcomes

    Multiple novel multi-port robotic surgical systems have been introduced into clinical practice. This systematic review aims to evaluate the clinical outcomes of these novel robotic systems to conventional lapa...

    Yit J. Leang, Joseph C. H. Kong, Zahin Mosharaf in Journal of Robotic Surgery (2024)

  3. Article

    Open Access

    Bariatric Surgery Efficiency, Safety and Health Outcomes in Government Versus Privately Funded Hospitals

    This study aims to determine if the hospital efficiency, safety and health outcomes are equal in patients who receive bariatric surgery in government-funded hospitals (GFH) versus privately funded hospitals (P...

    Chiara Chadwick, Paul R. Burton, Dianne Brown, Jennifer F. Holland in Obesity Surgery (2023)

  4. Article

    Open Access

    Comprehensive Analysis of Improvements in Health-Related Quality of Life and Establishment of QALY Gains in a Government-Funded Bariatric Surgical Program with 5-Year Follow-up

    Bariatric surgery is an efficacious intervention for substantial and sustained weight reduction in individuals with morbid obesity resulting in health improvements. However, the changes to a patient’s health r...

    Chiara Chadwick, Paul R. Burton, Jennifer Reilly, Julie Playfair in Obesity Surgery (2022)

  5. Article

    Open Access

    Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control

    Non-alcoholic steatohepatitis (NASH) and type 2 diabetes are closely linked, yet the pathophysiological mechanisms underpinning this bidirectional relationship remain unresolved. Using proteomic approaches, we...

    Magdalene K. Montgomery, Jacqueline Bayliss, Shuai Nie in Nature Communications (2022)

  6. Article

    Correction to: Improving Compliance with Very Low Energy Diets (VLEDs) Prior to Bariatric Surgery—A Randomized Controlled Trial of Two Formulations

    In the original article the name of author Alexandra Klejn was misspelled.

    Lucy Davenport, Yazmin Johari, Alexandra Klejn, Cheryl Laurie in Obesity Surgery (2019)

  7. Article

    Open Access

    Better governance, better access: practising responsible data sharing in the METADAC governance infrastructure

    Genomic and biosocial research data about individuals is rapidly proliferating, bringing the potential for novel opportunities for data integration and use. The scale, pace and novelty of these applications ra...

    Madeleine J. Murtagh, Mwenza T. Blell, Olly W. Butters, Lorraine Cowley in Human Genomics (2018)

  8. Article

    Open Access

    The ECOUTER methodology for stakeholder engagement in translational research

    Because no single person or group holds knowledge about all aspects of research, mechanisms are needed to support knowledge exchange and engagement. Expertise in the research setting necessarily includes scien...

    Madeleine J. Murtagh, Joel T. Minion, Andrew Turner in BMC Medical Ethics (2017)

  9. Article

    Author Reply—Bariatric Surgery and Liver Function Tests in Nonalcoholic Fatty Liver Disease

    Geraldine J. Ooi, Paul R. Burton, William W. Kemp, Stuart K. Roberts in Obesity Surgery (2017)

  10. Article

    Erratum to: Laparoscopic Adjustable Gastric Banding in Patients With Unexpected Cirrhosis: Safety and Outcomes

    Richard M. Woodford, Paul R. Burton, Paul E. O’Brien, Cheryl Laurie in Obesity Surgery (2015)

  11. Article

    Open Access

    Realizing the promise of population biobanks: a new model for translation

    The promise of science lies in expectations of its benefits to societies and is matched by expectations of the realisation of the significant public investment in that science. In this paper, we undertake a metho...

    Madeleine J. Murtagh, Ipek Demir, Jennifer R. Harris, Paul R. Burton in Human Genetics (2011)

  12. Article

    Open Access

    Longitudinal variance components models for systolic blood pressure, fitted using Gibbs sampling

    This paper describes an analysis of systolic blood pressure (SBP) in the Genetic Analysis Workshop 13 (GAW13) simulated data. The main aim was to assess evidence for both general and specific genetic effects o...

    Katrina J Scurrah, Martin D Tobin, Paul R Burton in BMC Genetics (2003)

  13. Article

    Open Access

    Genome-wide linkage analysis of longitudinal phenotypes using σ2A random effects (SSARs) fitted by Gibbs sampling

    The study of change in intermediate phenotypes over time is important in genetics. In this paper we explore a new approach to phenotype definition in the genetic analysis of longitudinal phenotypes. We utilize...

    Lyle J Palmer, Katrina J Scurrah, Martin Tobin, Sanjay R Patel in BMC Genetics (2003)