45 Result(s)

Article

Liver-derived extracellular vesicles improve whole-body glycaemic control via inter-organ communication

Small extracellular vesicles (EVs) are signalling messengers that regulate inter-tissue communication through delivery of their molecular cargo. Here, we show that liver-derived EVs are acute regulators of who...

Paula M. Miotto, Chieh-Hsin Yang, Stacey N. Keenan, William De Nardo… in Nature Metabolism (2024)

Article

Evaluation of the histological variability of core and wedge biopsies in nonalcoholic fatty liver disease in bariatric surgical patients

Liver biopsy remains the gold standard for characterizing and evaluating treatment response in nonalcoholic fatty liver disease (NAFLD). Liver heterogeneity and sampling variability can affect the reliability ...

Geraldine J. Ooi, Andrew Clouston, Yazmin Johari, William W. Kemp… in Surgical Endoscopy (2021)

Article

Bariatric Surgery in Patients with Severe Heart Failure

Obesity and cardiac failure are globally endemic and increasingly intersecting. Bariatric surgery may improve cardiac function and act as a bridge-to-transplantation. We aim to identify effects of bariatric su...

Tze Wei Wilson Yang, Yazmin Johari, Paul R Burton, Arul Earnest… in Obesity Surgery (2020)

Article

Improving Compliance with Very Low Energy Diets (VLEDs) Prior to Bariatric Surgery—a Randomised Controlled Trial of Two Formulations

Preoperative very low energy diets (VLEDs) improve access during bariatric surgery. Compliance with traditional VLED is variable, mainly due to gastrointestinal side effects. Formulite™ is a new formulation of...

Lucy Davenport, Yazmin Johari, Alexandria Klejn, Cheryl Laurie… in Obesity Surgery (2019)

Article

Reply to “Crashing NASH in Patients Listed for Bariatric Surgery”

Geraldine J. Ooi, Paul R. Burton, William W. Kemp, Stuart K. Roberts… in Obesity Surgery (2019)

Article

Effect of Body Mass Index, Metabolic Health and Adipose Tissue Inflammation on the Severity of Non-alcoholic Fatty Liver Disease in Bariatric Surgical Patients: a Prospective Study

Non-alcoholic fatty liver disease (NAFLD), driven by the obesity epidemic, has become the most common form of liver disease. Despite this, there is controversy regarding the prevalence and severity of NAFLD in...

Geraldine J. Ooi, Paul R. Burton, Jacqueline Bayliss, Arthe Raajendiran… in Obesity Surgery (2019)

Article

Evaluating feasibility and accuracy of non-invasive tests for nonalcoholic fatty liver disease in severe and morbid obesity

In obese individuals, nonalcoholic fatty liver disease (NAFLD) is common but often goes undiagnosed, and therefore untreated. The presence of significant fibrosis is a key determinant of NAFLD progression, and...

Geraldine J. Ooi, Arul Earnest, William W. Kemp… in International Journal of Obesity (2018)

Article

Detailed Description of Change in Serum Cholesterol Profile with Incremental Weight Loss After Restrictive Bariatric Surgery

Dyslipidemia affects up to 75% of morbidly obese individuals and is a key driver of cardiovascular disease. Weight loss is an established strategy to improve metabolic risk, including dyslipidemia. We aimed to...

Geraldine J. Ooi, Arul Earnest, Lisa Doyle, Cheryl Laurie… in Obesity Surgery (2018)

Article

Diabetes Outcomes More than a Decade Following Sustained Weight Loss After Laparoscopic Adjustable Gastric Band Surgery

Long-term outcome data are needed to define the role of bariatric surgery in type 2 diabetes (T2D). To address this, we collated diabetes outcomes more than a decade after laparoscopic adjustable gastric band ...

John M. Wentworth, Chloe Cheng, Cheryl Laurie, Stewart Skinner… in Obesity Surgery (2018)

Article

Visual Liver Score to Stratify Non-Alcoholic Steatohepatitis Risk and Determine Selective Intraoperative Liver Biopsy in Obesity

Non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), are endemic in obesity. We aimed to evaluate the diagnostic accuracy and reproducibility of a simple in...

Geraldine J. Ooi, Paul R. Burton, Arul Earnest, Cheryl Laurie… in Obesity Surgery (2018)

Article

The Physiology and Pathophysiology of Gastroesophageal Reflux in Patients with Laparoscopic Adjustable Gastric Band

The effect of the laparoscopic adjustable gastric band (LAGB) on esophageal acid exposure and reflux is poorly understood. Optimal technique and normative values for acid exposure have not been established in ...

Richard Y. Chen, Paul R. Burton, Geraldine J. Ooi, Cheryl Laurie… in Obesity Surgery (2017)

Article

Effects of Bariatric Surgery on Liver Function Tests in Patients with Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) affects over 80% of obese patients and is fueled by the metabolic syndrome. Weight loss is strongly advocated as a central treatment for NAFLD and has been shown to ind...

Geraldine J. Ooi, Paul R. Burton, Lisa Doyle, John M. Wentworth… in Obesity Surgery (2017)

Article

Changes in Outcomes, Satiety and Adverse Upper Gastrointestinal Symptoms Following Laparoscopic Adjustable Gastric Banding

Patient-reported outcomes and perceptions are critical to the overall efficacy and acceptability of a surgical procedure. Outcomes, such as patient satisfaction and perceived success of the surgery and adverse...

Paul R Burton, Geraldine J Ooi, Cheryl Laurie, Margaret Anderson… in Obesity Surgery (2017)