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Article
Open AccessTargeting the SphK1/S1P/PFKFB3 axis suppresses hepatocellular carcinoma progression by disrupting glycolytic energy supply that drives tumor angiogenesis
Hepatocellular carcinoma (HCC) remains a leading life-threatening health challenge worldwide, with pressing needs for novel therapeutic strategies. Sphingosine kinase 1 (SphK1), a well-established pro-cancer e...
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Article
Open AccessVascular senescence and leak are features of the early breakdown of the blood–brain barrier in Alzheimer’s disease models
Alzheimer’s disease (AD) is an age-related disease, with loss of integrity of the blood–brain barrier (BBB) being an early feature. Cellular senescence is one of the reported nine hallmarks of aging. Here, we ...
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Article
Open AccessCOVID-19 Outcomes in Minority Ethnic Groups: Do Obesity and Metabolic Risk Play a Role?
Globally, minority ethnic groups have been at higher risk of COVID-19 mortality and morbidity than majority populations. This review outlines factors that may interact to create these inequalities and explores...
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Article
Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models
A major feature of diabetic retinopathy is breakdown of the blood–retinal barrier, resulting in macular oedema. We have developed a novel oligonucleotide-based drug, CD5-2, that specifically increases expressi...
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Protocol
Epigenetics of Cognition and Neurodegenerative Disorders
Epigenetics is defined as alterations in RNA transcript expression, or the phenotype of the cell, that are caused by mechanisms other than changes in the associated DNA sequence. This chapter focuses on the ge...
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Article
Dual In Vivo Quantification of Integrin-targeted and Protease-activated Agents in Cancer Using Fluorescence Molecular Tomography (FMT)
Integrins, especially αvβ3 and αvβ5, are upregulated in tumor cells and activated endothelial cells and as such, serve as cancer biomarkers. We developed a novel near-infrared-labeled optical agent for the in viv...
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Article
Open AccessConstraints to estimating the prevalence of trypanosome infections in East African zebu cattle
In East Africa, animal trypanosomiasis is caused by many tsetse transmitted protozoan parasites including Trypanosoma vivax, T. congolense and subspecies of T. brucei s.l. (T. b. brucei and zoonotic human infecti...
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Article
Extremely strong carbon monoxide emission from the Cloverleaf quasar at a redshift of 2.5
GALAXIES at high redshift are very faint and difficult to study at optical and near-infrared wavelengths, but detection of far-infrared emission1 and molecular gas2,3 in a galaxy at redshift z≈2.3 has suggested t...
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Chapter and Conference Paper
Structure Function Relationships of Sustained on Ganglion Cells of the Mudpuppy Retina
The technique of whole cell recording (WCR) with patch clamp micropipettes has provided new insights into the properties of nerve cells (Hamill et. al., 1981). This method has received its widest application i...
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Article
Space: a new phase?
Keith Runcorn and Paul Coleman describe plans for a major new effort in exploration and urge more European cooperation
