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    Quantitative Systems Toxicology and Drug Development: The DILIsym Experience

    DILIsym® is a Quantitative Systems Toxicology (QST) model that has been developed over the last decade by a public-private partnership to predict the liver safety liability in new drug candidates. DILIsym integra...

    Paul B. Watkins in Systems Medicine (2022)

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    Article

    Stable isotope resolved metabolomics of primary human hepatocytes reveals a stressed phenotype

    The development of techniques allowing the culturing of primary mammalian hepatocytes has provided great insights into liver physiology. For most applications, it is desirable for hepatocytes in culture to mim...

    Jason H. Winnike, Peter Pediaditakis, Justyna E. Wolak… in Metabolomics (2012)