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Open AccessComprehensive characterization of IFNγ signaling in acute myeloid leukemia reveals prognostic and therapeutic strategies
Interferon gamma (IFNγ) is a critical cytokine known for its diverse roles in immune regulation, inflammation, and tumor surveillance. However, while IFNγ levels were elevated in sera of most newly diagnosed a...
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Article
Open AccessSingle cell T cell landscape and T cell receptor repertoire profiling of AML in context of PD-1 blockade therapy
In contrast to the curative effect of allogenic stem cell transplantation in acute myeloid leukemia via T cell activity, only modest responses are achieved with checkpoint-blockade therapy, which might be expl...
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Open AccessNivolumab maintenance in high-risk acute myeloid leukemia patients: a single-arm, open-label, phase II study
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Open AccessFollicular lymphoma patients with KIR2DL2 and KIR3DL1 and their ligands (HLA-C1 and HLA-Bw4) show improved outcome when receiving rituximab
The ECOG-ACRIN Cancer Research Group evaluated rituximab treatment schedules for patients with newly-diagnosed low-tumor-burden follicular-lymphoma (FL). All patients received 4-weekly rituximab treatments as ...
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End Stage Renal Disease – Treatment Options: Dialysis Versus Transplant
Treatment option for patients with end stage renal disease (ESRD) include dialysis and kidney transplantation. Patients with ESRD are at an increased risk for cardiovascular events, mortality and hospitalizati...
