14 Result(s)

Article

A 4-gene signature from histologically normal surgical margins predicts local recurrence in patients with oral carcinoma: clinical validation

Prognostic biomarkers for recurrence of Oral Squamous Cell Carcinoma (OSCC) are urgently needed. We aimed to independently validate a 4-gene expression signature (MMP1, COL4A1, P4HA2, THBS2) predictive of OSCC re...

Patricia P. Reis, Tomas Tokar, Rashmi S. Goswami, Yali Xuan… in Scientific Reports (2020)

Article

Identification of potential molecular pathogenesis mechanisms modulated by microRNAs in patients with Intestinal Neuronal Dysplasia type B

This study proposed to determine global microRNA (miRNA) expression and miRNA-regulated pathways in Intestinal Neuronal Dysplasia type B (IND-B). Fifty patients (0–15 years old) with IND-B were included in the...

Marcos C. Angelini, Alana Maia e. Silva, Tainara F. Felix… in Scientific Reports (2019)

Article

Large-scale discovery of previously undetected microRNAs specific to human liver

MicroRNAs (miRNAs) are crucial regulators of gene expression in normal development and cellular homeostasis. While miRNA repositories contain thousands of unique sequences, they primarily contain molecules tha...

Brenda C. Minatel, Victor D. Martinez, Kevin W. Ng, Adam P. Sage… in Human Genomics (2018)

Article

Integration of miRNA and mRNA expression profiles reveals microRNA-regulated networks during muscle wasting in cardiac cachexia

Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during...

Leonardo N. Moraes, Geysson J. Fernandez, Ivan J. Vechetti-Júnior… in Scientific Reports (2017)

Article

Integrative meta-analysis identifies microRNA-regulated networks in infantile hemangioma

Hemangioma is a common benign tumor in the childhood; however our knowledge about the molecular mechanisms of hemangioma development and progression are still limited. Currently, microRNAs (miRNAs) have been s...

Natália Bertoni, Lied M. S. Pereira, Fábio E. Severino… in BMC Medical Genetics (2016)

Article

miRNA expression in human lung cancer and fetal lung: a comparative study

Daiana D Becker-Santos, Kelsie L Thu, Patricia P Reis, Wendy P Robinson… in BMC Proceedings (2013)

Article

A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence

Oral Squamous Cell Carcinoma (OSCC) is a major cause of cancer death worldwide, which is mainly due to recurrence leading to treatment failure and patient death. Histological status of surgical margins is a cu...

Patricia P Reis, Levi Waldron, Bayardo Perez-Ordonez, Melania Pintilie… in BMC Cancer (2011)

Article

mRNA transcript quantification in archival samples using multiplexed, color-coded probes

A recently developed probe-based technology, the NanoString nCounter™ gene expression system, has been shown to allow accurate mRNA transcript quantification using low amounts of total RNA. We assessed the abi...

Patricia P Reis, Levi Waldron, Rashmi S Goswami, Wei Xu, Yali Xuan… in BMC Biotechnology (2011)

Article

Programmed cell death 4 loss increases tumor cell invasion and is regulated by miR-21 in oral squamous cell carcinoma

The tumor suppressor Programmed Cell Death 4 (PDCD4) has been found to be under-expressed in several cancers and associated with disease progression and metastasis. There are no current studies characterizing PDC...

Patricia P Reis, Miranda Tomenson, Nilva K Cervigne, Jerry Machado… in Molecular Cancer (2010)

Article

Optimization and analysis of a quantitative real-time PCR-based technique to determine microRNA expression in formalin-fixed paraffin-embedded samples

MicroRNAs (miRs) are non-coding RNA molecules involved in post-transcriptional regulation, with diverse functions in tissue development, differentiation, cell proliferation and apoptosis. miRs may be less pron...

Rashmi S Goswami, Levi Waldron, Jerry Machado, Nilva K Cervigne… in BMC Biotechnology (2010)

Article

Low prevalence of Human Papillomavirus in oral cavity carcinomas

Increasing evidence shows that Human Papillomavirus (HPV) is preferentially associated with some head and neck squamous cell carcinomas (HNSCCs), with variable infection rates reported.

Jerry Machado, Patricia P Reis, Tong Zhang, Colleen Simpson, Wei Xu… in Head & Neck Oncology (2010)

Article

microRNA evaluation of unknown primary lesions in the head and neck

Unknown primary malignancy in the head and neck is not an infrequent diagnosis for patients with metastatic cervical lymph nodes. Although linked with a relatively good prognosis following radiation treatment,...

Emma V Barker, Nilva K Cervigne, Patricia P Reis, Rashmi S Goswami… in Molecular Cancer (2009)