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  1. No Access

    Article

    Critical Role of Nitric Oxide During the Apoptosis of Peripheral Blood Leukocytes from Patients with AIDS

    Highly active antiretroviral therapies (HAART) increase the CD4+ cell count, but complete normalization of this parameter has not been obtained in some patients. As oxidative stress plays an important role during...

    Dr. M. Djavad Mossalayi, Pierre-André Becherel, Patrice Debré in Molecular Medicine (1999)

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    Article

    Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients

    Ebola virus is very pathogenic in humans. It induces an acute hemorrhagic fever that leads to death in about 70% of patients1. We compared the immune responses of patients who died from Ebola virus disease with t...

    Sylvain Baize, Eric M. Leroy, M.-C. Georges-Courbot, Monique Capron… in Nature Medicine (1999)

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    Perturbation of CD4+ and CD8+ T-cell repertoires during progression to AIDS and regulation of the CD4+ repertoire during antiviral therapy

    The T-cell antigen receptor (TCR) repertoire was studied longitudinally by analyzing the varying lengths of the beta chain CDR3 hypervariable region during the course of HIV-1 infection and following combinati...

    Guy Gorochov, Avidan U. Neumann, Anne Kereveur, Christophe Parizot… in Nature Medicine (1998)

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    Article

    Inducible Nitric Oxide Synthase and Proinflammatory Cytokine Expression by Human Keratinocytes during Acute Urticaria

    IgE/allergen-dependent activation of skin mast cells is involved in acute urticaria and leads to their EL-4 release. Previously we have demonstrated in vitro the induction of the low-affinity receptor for IgE ...

    Pierre-André Bécherel, Olivier Chosidow, Liliane Le Goff… in Molecular Medicine (1997)