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Article
Open AccessSystematic analysis of RNA-binding proteins identifies targetable therapeutic vulnerabilities in osteosarcoma
Osteosarcoma is the most common primary malignant bone tumor with a strong tendency to metastasize, limiting the prognosis of affected patients. Genomic, epigenomic and transcriptomic analyses have demonstrate...
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Article
Role of Grape (Vitis vinifera) Extracts of Different Cultivars Against γ-Radiation Induced DNA Damage and Gene Expression in Human Lymphocytes
Radiation therapy uses ionizing radiation (IR) to kill cancer cells. However, during radiotherapy normal cells are also damaged and killed by the generation of reactive oxygen species. Polyphenolic compounds a...
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Article
Open Accessp53 and HuR combinatorially control the biphasic dynamics of microRNA-125b in response to genotoxic stress
Post-transcriptional regulation of p53, by the microRNA miR-125b and the RNA-binding protein HuR, controls p53 expression under genotoxic stress. p53 mRNA translation is repressed by miR-125b, tightly regulati...
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Article
Open AccessNegative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation
The E3 ubiquitin ligase TRIM21 plays a crucial role as a negative regulator of innate immune responses. Recent evidence has also indicated the involvement of TRIM21 in the genotoxic stress response and suppres...
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Article
A stress-responsive RNA switch regulates VEGFA expression
RNA switches or riboswitches, involving the binding of small ligands to RNAs, are known to regulate gene expression in bacteria, fungi and plants, where they frequently respond to a deficit or excess of variou...
