23 Result(s)
within
Paolo Colombo
Biomedicine
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Article
The effect of residual water on antacid properties of sucralfate gel dried by microwaves
The aim of this work was to study the acid neutralization characteristics of microwave-dried sucralfate gel in relation to the water content and physical structure of the substance. Several dried sucralfate ge...
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Article
Accessorized DPI: a Shortcut towards Flexibility and Patient Adaptability in Dry Powder Inhalation
In this work, a novel powder dispersion add-on device, the AOS (Axial Oscillating Sphere), was studied in conjunction with commercially available DPI devices to improve the powder dispersion.
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Article
Biological Effects of Simvastatin Formulated as pMDI on Pulmonary Epithelial Cells
The aim of this study is to evaluate the biological effects of Calu-3 epithelial cells in response to the delivery of simvastatin (SV) via solution pressurized metered dose inhaler (pMDI).
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Article
Novel Simvastatin Inhalation Formulation and Characterisation
Simvastatin (SV), a drug of the statin class currently used orally as an anti-cholesterolemic via the inhibition of the 3-hydroxy-3-methyl-glutaryl-Coenzyme A (HMG-CoA) reductase, has been found not only to reduc...
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Article
Agglomerated Oral Dosage Forms of Artemisinin/β-Cyclodextrin Spray-Dried Primary Microparticles Showing Increased Dissolution Rate and Bioavailability
Artemisinin, a poorly water-soluble antimalarial drug, presents a low and erratic bioavailability upon oral administration. The aim of this work was to study an agglomerated powder dosage form for oral adminis...
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Article
Chlorhexidine Salt-Loaded Polyurethane Orthodontic Chains: In Vitro Release and Antibacterial Activity Studies
The widespread use of indwelling medical devices has enormously increased the interest in materials incorporating antibiotics and antimicrobial agents as a means to prevent dangerous device-related infections....
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Chapter
Geometric Release Systems: Principles, Release Mechanisms, Kinetics, Polymer Science, and Release-Modifying Material
Geometrical features such as shape and surface area of a drug-releasing matrix affect drug release kinetics by changing diffusion rates across the matrix, lengthening the diffusion pathway through drug–matrix ...
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Article
Cloning and expression of a novel component of the CAP superfamily enhanced in the inflammatory response to LPS of the ascidian Ciona intestinalis
The CAP superfamily is a group of proteins that have been linked to several biological functions such as reproduction, cancer, and immune defense. A differential screening between lipopolysaccharide (LPS)-chal...
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Article
Encapsulation of Ketoprofen and Ketoprofen Lysinate by Prilling for Controlled Drug Release
In this paper, ketoprofen and ketoprofen lysinate were used as model drugs in order to investigate release profiles of poorly soluble and very soluble drug from sodium alginate beads manufactured by prilling. ...
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Article
Therapeutic Paint of Cidofovir/Sucralfate Gel Combination Topically Administered by Spraying for Treatment of orf virus Infections
The aim of the research was to study a new cidofovir/sucralfate drug product to be used as a spray for treating the mucosal and/or skin lesions. The product, i.e., a water suspension of sucralfate (15% w/w) and c...
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Article
Agglomerates Containing Pantoprazole Microparticles: Modulating the Drug Release
Pantoprazole-loaded microparticles were prepared using a blend of Eudragit® S100 and Methocel® F4M. The accelerated stability was carried out during 6 months at 40°C and 75% relative humidity. In order to impr...
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Article
Pulmonary Spray Dried Powders of Tobramycin Containing Sodium Stearate to Improve Aerosolization Efficiency
Tobramycin microparticulate powders containing the hydrophobic adjunct sodium stearate were studied for their use as pulmonary formulations in dry powder inhalers.
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Article
Open AccessElectrophoresis of proteins and DNA on horizontal sodium dodecyl sulfate polyacrylamide gels
An inexpensive Plexiglas apparatus which allows a simple and rapid preparation of horizontal polyacrylamide gels of different dimensions for different purposes, is described. Preparation of such gels is as eas...
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Article
Release and permeation kinetics of caffeine from bioadhesive transdermal films
The aim of this work was to investigate, in vitro, the kinetics of release and permeation of caffeine, chosen as model drug, from bioadhesive transdermal films. These films are not self-adhesive but become adh...
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Article
The surface roughness of lactose particles can be modulated by wet-smoothing using a high-shear mixer
The surface morphology of α-lactose monohydrate particles was modified by a new wet-smoothing process performed in a high-shear mixer using solvents. Successive steps of wetting and drying of lactose powders d...
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Article
The suitability of disintegrating force kinetics for studying the effect of manufacturing parameters on spironolactone tablet properties
The aim of this paper was to study the effect of the granulate properties and tablet compression force on disintegrating force behavior in order to investigate the capability of the disintegrating force to cha...
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Article
Physical and Chemical Enhancement of Transdermal Delivery of Triptorelin
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Article
Ionized Prodrugs of Dehydroepiandrosterone for Transdermal lontophoretic Delivery
Purpose. The aim of this work was to synthesize ionized dehydroepiandrosterone (DHEA) prodrugs with higher water solubility, useful for iontophoretic transdermal application.
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Article
Drug Reservoir Composition and Transport of Salmon Calcitonin in Transdermal Iontophoresis
Purpose. The aim of the work was to study iontophoretic transdermal administration of salmon calcitonin (sCt) in rabbits, with particular attention to drug reservoir composition. A dry sCt disc, to be dissolved ...
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Article
Delivery of Nasal Powders of β-Cyclodextrin by Insufflation
Purpose. Delivery of nasal powders of granulated β-cyclodextrin by insufflation was studied in order to find the relationship between powder properties and delivery behavior.
