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Chapter
Comparison of Four Different Fuller’s Earth Formulations in Skin Decontamination
Industrial accidents, wars and terrorist threats are potential sources of skin contamination by highly toxic chemical warfare agents and manufacturing compounds. Here, we have compared fuller’s earth (FE) time...
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Article
Open AccessMinoxidil versus placebo in the treatment of arterial wall hypertrophy in children with Williams Beuren Syndrome: a randomized controlled trial
Insufficient elastin synthesis leads to vascular complications and arterial hypertension in children with Williams-Beuren syndrome. Restoring sufficient quantity of elastin should then result in prevention or ...
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Article
Open AccessLive-stream characterization of cadmium-induced cell death using visible CdTe-QDs
Characterization of cell death currently requires the use of indirect markers, which has largely limited the ability to monitor cell death processes inside the cell. Here, we introduce a new method for the cha...
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Reference Work Entry In depth
A Pharmaceutical Approach of Transcutaneous Oxygen Therapies
The skin is a multifunctional organ, acting as first line of defense by actively protecting from environmental stress caused by injury, microbial treat, UV irradiation, and toxic compounds. Skin equilibrium de...
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Reference Work Entry In depth
Skin Barrier Function
Adaptation to terrestrial life necessitates the presence of a highly impermeable epidermal membrane which restrains both insensible water loss from the body (transepidermal water loss; TEWL) and the entrance o...
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Living Reference Work Entry In depth
Skin Barrier Function
Adaptation to terrestrial life necessitates the presence of a highly impermeable epidermal membrane which restrains both insensible water loss from the body (transepidermal water loss; TEWL) and the entrance o...
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Article
New easy handling and sampling device for bioavailability screening of topical formulations
Biopharmaceutical assessment of topical drug formulations is widely carried out by using vertical diffusion cells (Franz type cell). Although Franz diffusion cell model is well designed for percutaneous absorp...
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Chapter
Thermosensitive Hydrogels in Dermatology: A Multidisciplinary Overview
Formulation of dermatological medicines in hospitals is a multidisciplinary challenge addressing pharmaceutical issues such as (1) excipient availability and safety, (2) drug solubility and diffusivity, (3) dr...
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Chapter
Influence of Excipients on Two Elements of the Stratum Corneum Barrier: Intercellular Lipids and Epidermal Tight Junctions
The skin is one of the most important organs in the human body due to its crucial role as an interface between the internal and external environments. Homeostasis and permeability of the skin barrier are regul...
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Article
Chlorhexidine Salt-Loaded Polyurethane Orthodontic Chains: In Vitro Release and Antibacterial Activity Studies
The widespread use of indwelling medical devices has enormously increased the interest in materials incorporating antibiotics and antimicrobial agents as a means to prevent dangerous device-related infections....
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Chapter
Glycerol as a Skin Barrier Influencing Humectant
Glycerol, obtained mainly by saponification of oils and fats, is an important ingredient in pharmaceutical and cosmetic preparations. It acts as a humectant due mostly to its high hygroscopic property.
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Article
Effects of glycerol on human skin damaged by acute sodium lauryl sulphate treatment
Glycerol, widely used as humectant, is known to protect against irritants and to accelerate recovery of irritated skin. However, most studies were done with topical formulations (i.e. emulsions) containing gly...
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Article
Effects of physical and chemical treatments upon biophysical properties and micro-relief of human skin
The aim of the present study was to determine the attendant effects of physical (tape-strip**) and chemical (three commercial hydrating formulations) treatments upon biophysical and micro-relief properties o...
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Article
Qualitative and quantitative comparison of heat separated epidermis and dermatomed skin in percutaneous absorption studies
Transepidermal water loss (TEWL), mainly regulated by the stratum corneum, was quantitatively correlated to percutaneous absorption of compounds in human and suggested for the ex vivo assessment of skin integr...
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Article
Chemical Uptake Into Human Stratum Corneum In Vivo from Volatile and Non-Volatile Solvents
Purpose. Simple, safe and quick in vivo methods for estimating chemical uptake into the stratum corneum (SC) from volatile and non-volatile solvents are invaluable to health risk assessors. This study compares t...
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Article
Stratum Corneum Thickness and Apparent Water Diffusivity: Facile and Noninvasive Quantitation In Vivo
