52 Result(s)

Article

Assessment of differentially methylated loci in individuals with end-stage kidney disease attributed to diabetic kidney disease: an exploratory study

A subset of individuals with type 1 diabetes mellitus (T1DM) are predisposed to develo** diabetic kidney disease (DKD), the most common cause globally of end-stage kidney disease (ESKD). Emerging evidence su...

L. J. Smyth, J. Kilner, V. Nair, H. Liu, E. Brennan, K. Kerr… in Clinical Epigenetics (2021)

Article

Podocyte apoptosis is prevented by blocking the Toll-like receptor pathway

High serum lipopolysaccharide (LPS) activity in normoalbuminuric patients with type 1 diabetes (T1D) predicts the progression of diabetic nephropathy (DN), but the mechanisms behind this remain unclear. We obs...

P Saurus, S Kuusela, E Lehtonen, M E Hyvönen, M Ristola… in Cell Death & Disease (2015)

Article

HbA_1c variability is associated with an increased risk of retinopathy requiring laser treatment in type 1 diabetes

This study aimed to investigate whether variation in long-term glycaemia in type 1 diabetes as measured by HbA_1c variability is associated with the cumulative incidence and risk of retinopathy requiring laser tre...

K. Hietala, J. Wadén, C. Forsblom, V. Harjutsalo, J. Kytö, P. Summanen… in Diabetologia (2013)

Article

HLA class II is a factor in cardiovascular morbidity and mortality rates in patients with type 1 diabetes

Patients with type 1 diabetes and kidney disease have a higher risk of cardiovascular events. HLA class II genes are expressed on infiltrated inflammatory cells and smooth-muscle cells in atherosclerotic plaqu...

J. Söderlund, C. Forsblom, J. Ilonen, L. M. Thorn, J. Wadén, M. Parkkonen… in Diabetologia (2012)

Article

SNP in the genome-wide association study hotspot on chromosome 9p21 confers susceptibility to diabetic nephropathy in type 1 diabetes

Parental type 2 diabetes mellitus increases the risk of diabetic nephropathy in offspring with type 1 diabetes mellitus. Several single nucleotide polymorphisms (SNPs) that predispose to type 2 diabetes mellit...

E. Fagerholm, E. Ahlqvist, C. Forsblom, N. Sandholm, A. Syreeni… in Diabetologia (2012)

Article

Hyperfiltration in type 1 diabetes: does it exist and does it matter for nephropathy?

Hyperfiltration is widely regarded as a contributing factor to the development of microalbuminuria and progressive nephropathy in type 1 diabetes. However, recent studies have questioned this conclusion.

M. C. Thomas, J. L. Moran, V. Harjutsalo, L. Thorn, J. Wadén, M. Saraheimo… in Diabetologia (2012)

Article

Discovery of early-stage biomarkers for diabetic kidney disease using ms-based metabolomics (FinnDiane study)

Diabetic kidney disease (DKD) is a devastating complication that affects an estimated third of patients with type 1 diabetes mellitus (DM). There is no cure once the disease is diagnosed, but early treatment a...

F. M. van der Kloet, F. W. A. Tempels, N. Ismail, R. van der Heijden… in Metabolomics (2012)

Article

Purchase of antidepressant agents by patients with type 1 diabetes is associated with increased mortality rates in women but not in men

Individuals with diabetes have increased mortality rates compared with the general population. In patients with type 2 diabetes depression further contributes to the increased mortality. Depression and mortali...

A. J. Ahola, V. Harjutsalo, M. Saraheimo, C. Forsblom, P.-H. Groop in Diabetologia (2012)

Article

Soluble receptor for AGE (RAGE) is a novel independent predictor of all-cause and cardiovascular mortality in type 1 diabetes

Activation of the receptor for AGE (RAGE) is implicated in the development and progression of vascular complications of diabetes. In this study, we explore factors and mortality outcomes associated with solubl...

M. C. Thomas, J. Söderlund, M. Lehto, V.-P. Mäkinen, J. L. Moran… in Diabetologia (2011)

Article

Sex-related differences in the long-term risk of microvascular complications by age at onset of type 1 diabetes

This study examined sex-related differences in the cumulative risk of proliferative retinopathy (PR) and end-stage renal disease (ESRD) over 40 years of duration of type 1 diabetes according to age at diabetes...

V. Harjutsalo, C. Maric, C. Forsblom, L. Thorn, J. Wadén, P. H. Groop in Diabetologia (2011)

Article

Short-term oxygen administration restores blunted baroreflex sensitivity in patients with type 1 diabetes

We hypothesised that the blunted baroreflex sensitivity (BRS) typical of type 1 diabetes is caused by a higher degree of tissue hypoxia in diabetes, and tested whether oxygen increased BRS and ventilation less...

L. Bernardi, M. Rosengård-Bärlund, A. Sandelin, V. P. Mäkinen, C. Forsblom… in Diabetologia (2011)

Article

Comorbidities and survival of patients with type 1 diabetes on renal replacement therapy

Comorbidities are frequent among type 1 diabetes patients on renal replacement therapy, yet the effect of comorbidities on survival is unknown. Our aim was to estimate this effect.

J. Helve, M. Haapio, P.-H. Groop, C. Grönhagen-Riska, P. Finne in Diabetologia (2011)

Article

Deep breathing improves blunted baroreflex sensitivity even after 30 years of type 1 diabetes

Cardiovascular autonomic neuropathy is associated with increased morbidity in patients with type 1 diabetes. Although it is conventionally considered to be an organic, irreversible disorder, we previously demo...

M. Rosengård-Bärlund, L. Bernardi, J. Holmqvist, G. Debarbieri… in Diabetologia (2011)

Article

Erratum to: Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

J. M. Forbes, J. Söderlund, F. Y. T. Yap, M. Knip, S. Andrikopoulos… in Diabetologia (2011)

Article

Receptor for advanced glycation end-products (RAGE) provides a link between genetic susceptibility and environmental factors in type 1 diabetes

This group of studies examines human genetic susceptibility conferred by the receptor for advanced glycation end-products (RAGE) in type 1 diabetes and investigates how this may interact with a western environ...

J. M. Forbes, J. Söderlund, F. Y. T. Yap, M. Knip, S. Andrikopoulos… in Diabetologia (2011)

Article

Cumulative cost of prescription medication in outpatients with type 1 diabetes in Finland

We examined the 11-year cumulative outpatient cost of prescription medication in patients with type 1 diabetes by subgroups according to the presence of complications and duration of diabetes.

R. Lithovius, V. Harjutsalo, C. Forsblom, P. H. Groop in Diabetologia (2011)

Article

A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus

Homozygosity for a five leucine repeat (5L–5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We pr...

A. Alkhalaf, S. J. L. Bakker, H. J. G. Bilo, R. O. B. Gans, G. J. Navis… in Diabetologia (2010)

Article

DDOST, PRKCSH and LGALS3, which encode AGE-receptors 1, 2 and 3, respectively, are not associated with diabetic nephropathy in type 1 diabetes

The AGE receptors 1, 2 and 3, which are encoded by DDOST, PRKCSH and LGALS3, respectively, may be involved in the pathogenesis of diabetic complications. We sought to find out whether these genes are associated w...

A. Hoverfelt, R. Sallinen, J. M. Söderlund, C. Forsblom… in Diabetologia (2010)