13 Result(s)

Article

Introduction: Preface to the Hedgehog family of proteins review volume

P. W. Ingham, M. Placzek in Cellular and Molecular Life Sciences CMLS (2000)

Article

Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo

CELL patterning in the body segments of the Drosophila embryo requires activity of the segment polarity genes, a molecularly heterogeneous group defined by a generic mutant phenotype¹. Two of these genes, wingles...

P. W. Ingham in Nature (1993)

Article

Role of the Drosophila patched gene in positional signalling

AFTER cellularization of the Drosophila embryo, positional differences within each primordial segment are maintained and elaborated by processes that require cell interactions. The best-documented examples^1,2 of ...

P. W. Ingham, A. M. Taylor, Y. Nakano in Nature (1991)

Article

The X, Y, Z of head development

P. W. Ingham in Nature (1990)

Article

A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched

The patterning of cells in insect segments requires the exchange of information between cells, which in Drosophila depends on the activity of members of the segment-polarity class of genes. Here we report the mol...

Y. Nakano, I. Guerrero, A. Hidalgo, A. Taylor, J. R. S. Whittle, P. W. Ingham in Nature (1989)

Article

The molecular genetics of embryonic pattern formation in Drosophila

Analysis of the genes that control the early events of Drosophila embryogenesis is providing details of the molecular processes underlying the positional specification of cells. There are two distinct phases: the...

P. W. Ingham in Nature (1988)

Article

Regulation of segment polarity genes in the Drosophila blastoderm by fushi tarazu and even skipped

During the late cellular blastoderm stage of Drosophila embryogenesis the segmentation genes engrailed, en, and wingless, wg, become expressed in two series of 14 stripes^1–4 which will subsequently coincide with ...

P. W. Ingham, N. E. Baker, A. Martinez-Arias in Nature (1988)

Article

The correct activation of Antennapedia and bithorax complex genes requires the fushi tarazu gene

In the Drosophila embryo the establishment and specification of metameric units depends upon the selective activation of the segmentation^1,2 and the homoeotic selector genes^3,4. The former are necessary for estab...

P. W. Ingham, A. Martinez-Arias in Nature (1986)

Article

Transcription pattern of the Drosophila segmentation gene hairy

Segmentation of the Drosophila embryo requires expression of the pair-rule genes, mutations of which cause reiterated deletions in alternate segments along the antero-posterior body axis. We find that transcripts...

P. W. Ingham, K. R. Howard, D. Ish-Horowicz in Nature (1985)

Article

Drosophila genetics: Patterns of differentiation

P. W. Ingham in Nature (1985)

Article

Differential expression of bithorax complex genes in the absence of the extra sex combs and trithorax genes

Each body segment of Drosophila follows a unique developmental pathway, controlled by the selective expression of homoeotic genes such as Sex combs reduced (Scr)^1,2and the bithorax complex (BX-C)^3,4. Little is kn...

P. W. Ingham in Nature (1983)

Article

Trithorax: A new homoeotic mutation ofDrosophila melanogaster

New alleles of thetrithorax locus have been isolated and analysed. The phenotypes of different allelic combinations confirm that a decrease or loss of function of the locus is responsible for homoeotic transforma...

P. W. Ingham in Wilhelm Roux's archives of developmental biology (1981)