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  1. No Access

    Article

    Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model

    The plasma concentration–time profile of a drug is essential to explain the relationship between the administered dose and the kinetics of drug action. However, in some cases such as in pre-clinical pharmacolo...

    P. Jacqmin, E. Snoeck, E.A. van Schaick… in Journal of Pharmacokinetics and Pharmacody… (2007)

  2. No Access

    Article

    Population analysis of the non-linear red blood cell partitioning of draflazine following various infusion durations

    Objective: The pharmacokinetics and non-linear red blood cell partitioning of the nucleoside transport inhibitor draflazine were investigated in 19 healthy male and female subjects (age ...

    E. Snoeck, V. Piotrovskij, P. Jacqmin… in European Journal of Clinical Pharmacology (1997)

  3. No Access

    Article

    A study of lactate metabolism without tracer during passive and active postexercise recovery in humans

    Tracers have been used extensively to study lactate metabolism in humans during rest and exercise. Nevertheless, quantification of in vivo lactate kinetics as measured by lactate tracers remains controversial ...

    M. Francaux, P. Jacqmin… in European Journal of Applied Physiology and… (1995)

  4. No Access

    Article

    Irreversible binding to proteins after single and repeated daily oral administration of 4-(2,2-diphenylethyl) imidazole (SC-46264) to the Cynomolgus monkey

    SC-46264 is an antagonist of the α2-adrenergic receptor. Distribution and excretion of [14C]-SC-46264 were studied after single and repeated daily oral administrations to the Cynomolgus monkey at a 1.5 mg/kg dose...

    P. Jacqmin, M. Hérin, R. Cavalier, M. Lesne in European Journal of Drug Metabolism and Ph… (1993)