6 Result(s)

Article

Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling

Genetic insulin receptoropathies are a rare cause of severe insulin resistance. We identified the Ile119Met missense mutation in the insulin receptor INSR gene, previously reported in a Yemeni kindred, in four un...

E. Raffan, M. A. Soos, N. Rocha, A. Tuthill, A. R. Thomsen, C. S. Hyden… in Diabetologia (2011)

Article

Is there a human model for the ‘metabolic syndrome’ with a defined aetiology?

P. Gorden, B. C. Lupsa, A. Y. Chong, A. O. Lungu in Diabetologia (2010)

Article

Efficacy of leptin therapy in the different forms of human lipodystrophy

Lipodystrophy is a rare disorder characterised by loss of adipose tissue, hypoleptinaemia, severe insulin resistance, diabetes and dyslipidaemia. The aims of this study were to determine whether leptin replace...

A. Y. Chong, B. C. Lupsa, E. K. Cochran, P. Gorden in Diabetologia (2010)

Article

Relationship of binding to internalization of¹²⁵I-insulin in isolated rat hepatocytes

By quantitative electron microscopic autoradiographic technique, we have previously shown that¹²⁵I-insulin initially localizes to the plasma membrane of isolated rat hepatocytes and is subsequently internalized i...

J. -L. Carpentier, P. Gorden, P. Freychet, A. LeCam, L. Orci in Diabetologia (1979)

Article

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle

Autoantibodies against the insulin receptor are found in the serum of some patients with severe insulin resistance. The effects of one of these sera on insulin binding and on glucose transport and metabolism w...

Y. Le Marchand-Brustel, P. Gorden, J. S. Flier, C. R. Kahn, P. Freychet in Diabetologia (1978)

Article

Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states

The proportion of total plasma immunoreactive insulin comprising the proinsulin-like component was determined in 5 diabetic subjects manifesting fasting hyperglycemia, severe glucose intolerance, and insulinop...

P. Gorden, C. M. Hendricks, J. Roth in Diabetologia (1974)