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  1. Article

    Open Access

    Founder effect in the Horn of Africa for an insulin receptor mutation that may impair receptor recycling

    Genetic insulin receptoropathies are a rare cause of severe insulin resistance. We identified the Ile119Met missense mutation in the insulin receptor INSR gene, previously reported in a Yemeni kindred, in four un...

    E. Raffan, M. A. Soos, N. Rocha, A. Tuthill, A. R. Thomsen, C. S. Hyden… in Diabetologia (2011)

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  2. Article

    Is there a human model for the ‘metabolic syndrome’ with a defined aetiology?

    P. Gorden, B. C. Lupsa, A. Y. Chong, A. O. Lungu in Diabetologia (2010)

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  3. Article

    Efficacy of leptin therapy in the different forms of human lipodystrophy

    Lipodystrophy is a rare disorder characterised by loss of adipose tissue, hypoleptinaemia, severe insulin resistance, diabetes and dyslipidaemia. The aims of this study were to determine whether leptin replace...

    A. Y. Chong, B. C. Lupsa, E. K. Cochran, P. Gorden in Diabetologia (2010)

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  4. No Access

    Chapter

    Internalization of polypeptide hormones and receptor recycling

    The insulin receptor is an integral plasma membrane glycoprotein of most cells. It consists of 2 subunits linked by disulfide bonds; the alpha and beta subunits of the receptor are synthesized by way of a sing...

    J.-L Carpentier, P. Gorden, A. Robert, L. Orci in Development of Hormone Receptors (1987)

  5. No Access

    Article

    Internalization of polypeptide hormones and receptor recycling

    The insulin receptor is an integral protein of the plasma membrane of the cell. It is composed of two subunits: an α subunit, which binds the hormone, and a β subunit which is a tyrosine specific protein kinas...

    J. -L. Carpentier, P. Gorden, A. Robert, L. Orci in Experientia (1986)

  6. Article

    Relationship of binding to internalization of125I-insulin in isolated rat hepatocytes

    By quantitative electron microscopic autoradiographic technique, we have previously shown that125I-insulin initially localizes to the plasma membrane of isolated rat hepatocytes and is subsequently internalized i...

    J. -L. Carpentier, P. Gorden, P. Freychet, A. LeCam, L. Orci in Diabetologia (1979)

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  7. No Access

    Article

    125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures

    125I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that th...

    J. -L. Carpentier, P. Gorden, P. Freychet, A. Le Cam, L. Orci in Experientia (1979)

  8. Article

    Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle

    Autoantibodies against the insulin receptor are found in the serum of some patients with severe insulin resistance. The effects of one of these sera on insulin binding and on glucose transport and metabolism w...

    Y. Le Marchand-Brustel, P. Gorden, J. S. Flier, C. R. Kahn, P. Freychet in Diabetologia (1978)

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  9. Article

    Circulating proinsulin-like component in man: Increased proportion in hypoinsulinemic states

    The proportion of total plasma immunoreactive insulin comprising the proinsulin-like component was determined in 5 diabetic subjects manifesting fasting hyperglycemia, severe glucose intolerance, and insulinop...

    P. Gorden, C. M. Hendricks, J. Roth in Diabetologia (1974)

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