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Article
Targeted therapy in hormone refractory prostate cancer
Despite recent progress in the treatment of hormone refractory prostate cancer—with a survival advantage seen with docetaxel chemotherapy—there remains a need for further improvements in this important patient...
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Article
Open AccessFluorodeoxyglucose positron emission tomography in the evaluation of germ cell tumours at relapse
Differentiation of active disease from fibrosis/mature teratoma in patients with residual masses or identifying of sites of recurrence in patients with raised markers following treatment of their testicular ca...
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Article
Gender affects doxorubicin pharmacokinetics in patients with normal liver biochemistry
We studied the variability in doxorubicin pharmacokinetics in 27 patients, all of whom had normal liver biochemistry tests. Blood samples were collected after the first cycle of single-agent doxorubicin given ...
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Article
Comparative pharmacokinetics of doxorubicin given by three different schedules with equal dose intensity in patients with breast cancer
The pharmacokinetics of doxorubicin given according to three different schedules with a similar dosetime intensity have been studied and compared in 16 women with metastatic breast cancer. Six patients were tr...
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Article
Sequential chemotherapy in good-prognosis patients with small-cell lung cancer
A sequential combination chemotherapy regimen was evaluated in 23 patients with small-cell lung cancer (16, limited disease; 7, extensive disease). All patients had an Eastern Cooperative Oncology Group (ECOG)...
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Article
A phase II study of ifosfamide and cisplatin chemotherapy for metastatic or relapsed carcinoma of the cervix
A total of 44 women received a combination of ifosfamide (1.5 g/m2 daily x5) and cisplatin (50 mg/m2 on day 1 only) as first-line chemotherapy for recurrent or metastatic carcinoma of the cervix. In all, 12/42 (3...
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Article
Intensive chemotherapy with autologous bone marrow transplantation for small-cell lung cancer
Since 1980, 75 patients with small-cell lung cancer (SCLC) have been entered into four consecutive studies of high-dose chemotherapy using autologous bone marrow transplantation (ABMT) to assist haematological...
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Article
Effect of cancer chemotherapy on dapsone N-acetylation in man
The effect of cancer chemotherapy on dapsone (DDS) N-acetylation was explored in 28 patients with various malignancies. There was a significant (P=0.01) increase in plasma monoacetydapsone/dapsone (MADDS/DDS) rat...
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Article
A phase II study of ifosfamide in advanced and relapsed carcinoma of the cervix
Forty-one patients with advanced progressing carcinoma of the cervix were treated with ifosfamide 1.5 g/m2 daily in a 30-min infusion for 5 days every 3 weeks. The overall response rate (complete + partial) was 1...
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Article
Very high dose chemotherapy with autologous bone marrow rescue in adult patients with resistant relapsed lymphoma
Seventeen patients with advanced lymphoma were treated with high-dose chemotherapy with autologous bone marrow rescue. In 11 patients with non-Hodgkin's lymphoma (NHL) there were 2 complete remissions (CRs) an...
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Chapter
Intensive Chemotherapy with Autologous Bone Marrow Transplantation in Small Cell Carcinoma of the Lung
In spite of improvements in response rate with combination chemotherapy, median survival is poor in both limited and extensive disease. The best figures for median survival are 18 months in limited disease and...
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Chapter
Lung Cancer: Future Prospects
Since lung cancer is predominantly caused by smoking, future trends in the disease will be largely determined by what happens to smoking habits over the next few decades and this will be discussed in the next ...
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Article
Decreased plasma half-life of cyclophosphamide during repeated high-dose administration
Cyclophosphamide was given as IV doses of 50 mg/kg/day on each of four successive days as treatment for ovarian and lung cancer. Blood samples were taken at regular intervals and analysed for cyclophosphamide ...
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Article
High-dose cyclophosphamide with autologous marrow transplantation as initial treatment of small cell carcinoma of the bronchus
Sixteen patients with untreated small cell carcinoma of the bronchus received cyclophosphamide in a total dose of 160–200 mg/kg. Autologous marrow transplantation was used to minimise the period of hypoplasia ...
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Article
Epipodophyllotoxin (VP16-213) in small cell carcinoma of the bronchus resistant to initial combination chemotherapy
Thirty-eight patients with small cell carcinoma of the bronchus resistant to initial chemotherapy with cyclophosphamide methotrexate and CCNU, were treated with VP16-213 alone in a dose of 120 mg/m2 i.v. on days ...
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Chapter and Conference Paper
An Anharmonic Model for Molecular Photo-Excitation
Photo-excitation of polyatomic molecules occurs when sufficient laser energy is accepted by the near resonant dipole mode and transferred to the anharmonic dissociation mode. The theoretical problem then centr...
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Article
Authoritative text on quantum electronics
Quantum Electronics: A Treatise.
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Article
Superconducting flux structure probed with positive muons
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Chapter and Conference Paper
Peierls Instability in the Layer Semiconductor MoS2?
The electrical conductivity of pure crystals of 2H MoS2 has been measured at pressures up to 36 k bars. A two fold increase is observed between zero and 7 k bars. Theory is presented to relate this behaviour to a...
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Chapter
Light Absorption by Electrons in Polar Crystals in a Strong Magnetic Field
An optical phonon structure is proposed for cyclotron absorption in polar crystals at high magnetic fields. This is due to an induced modulation of the optical dipole by the electron phonon interaction. The th...
