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Article
Combined positive/negative selection for highly effective purging of PBPC grafts: towards clinical application in patients with B-CLL
Autologous PBPC transplantation is a potentially curative treatment for patients with chronic lymphocytic leukemia (CLL). As the autografts are frequently contaminated with large numbers of tumor cells, we hav...
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Article
Allogeneic peripheral blood progenitor cells for treatment of relapse after bone marrow transplantation
Donor leukocyte infusions (DLI) are an effective therapy for patients who relapse with leukemia after bone marrow transplantation (BMT). Severe graft-versus-host disease and prolonged periods of pancytopenia c...
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Article
Long-term disease-free survival of patients with advanced mantle-cell lymphoma following high-dose chemotherapy
In advanced stage mantle cell lymphoma, conventional chemotherapy yields a complete remission rate below 40%, and the median survival rate is only about 3 years. Between 1991 and 1996 we treated nine such pati...
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Article
Comparison of different strategies of molecular genetic monitoring following autologous stem cell transplantation in patients with follicular lymphoma
Two different molecular genetic methods were compared for their suitability for monitoring minimal residual disease in patients with follicular lymphoma (FL) treated with high-dose therapy and autologous stem ...
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Article
Autografting of highly purified peripheral blood progenitor cells following myeloablative therapy in patients with lymphoma: a prospective study of the long-term effects on tumor eradication, reconstitution of hematopoiesis and immune recovery
In a prospective study, we have investigated CD34+ selection of peripheral blood progenitor cells (PBPC) for autotransplantation in patients with lymphoma. Twenty-six consecutive patients (10 follicular lymphomas...
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Article
Hepatitis B viremia in a patient with documented previous HBV immunity after autologous transplantation of highly purified PBSC
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Article
Reduced-intensity allogeneic stem cell transplantation as salvage treatment for patients with indolent lymphoma or CLL after failure of autologous SCT
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Article
Elevated blood drug levels obtained from indwelling silicon catheters during oral cyclosporine A administration
Cyclosporine A (CsA) may be bound to and released from the inner surface of central venous catheters resulting in spuriously elevated blood drug levels. We observed this phenomenon in a boy transplanted becaus...
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Article
Enhanced antileukemic activity of allogeneic peripheral blood progenitor cell transplants following donor treatment with the combination of granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF) in a murine transplantation model
Allogeneic peripheral blood progenitor cells (PBPCs) have mostly been mobilized by granulocyte colony-stimulating factor (G-CSF). There is neither clinical nor experimental data available addressing the questi...
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Article
Reduced-intensity conditioning prior to allogeneic transplantation of hematopoietic stem cells: the need for T cells early after transplantation to induce a graft-versus-lymphoma effect
In patients with poor-risk relapse of aggressive lymphoma, reduced-intensity conditioning followed by allogeneic PBSCT may have its limitations because of rapid regrowth of the tumor. We tried to address this ...
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Article
Occurrence of donor-derived CLL 8 years after sibling donor SCT for CML
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Article
Pentostatin for treatment of steroid-refractory acute GVHD: a retrospective single-center analysis
Acute GVHD (aGVHD) remains a major cause of mortality in patients undergoing allo-SCT. In particular, the outcome of those patients who fail first-line therapy with glucocorticosteroids is poor. Preliminary re...
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Article
The EBMT activity survey: 1990–2010
A total of 654 centers from 48 countries were contacted for the 2010 survey. In all, 634 centers reported a total of 33 362 hematopoietic SCT (HSCT) with 30 012 patients receiving their first transplant (12 27...
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Article
Current status of hematopoietic cell transplantation in the treatment of systemic amyloid light-chain amyloidosis
Systemic amyloid light-chain (AL) amyloidosis is a protein conformation disorder caused by clonal plasma cell dyscrasias. Symptoms result from fibrillar extracellular deposits in various tissues. The deposits ...
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Article
Open AccessHematopoietic SCT in Europe: data and trends in 2011
In all, 651 from 680 centers in 48 countries reported 35 660 hematopoietic SCT (HSCT) in 32 075 patients (13 470 allogeneic (42%), 18 605 autologous (58%)) to the 2011 survey. Main indications were: leukemias;...
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Article
Open AccessRisk factors and containment of respiratory syncytial virus outbreak in a hematology and transplant unit
Respiratory syncytial virus (RSV) usually causes self-limiting upper respiratory tract infections, but can be associated with severe lower respiratory tract infection disease (LRTID) in infants and in patients...
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Article
Erratum: Prophylaxis and treatment of GVHD: EBMT–ELN working group recommendations for a standardized practice
Correction to: Bone Marrow Transplantation advance online publication, 29 July 2013; doi:10.1038/bmt.2013.107 Since the publication of this article the authors have noticed an error in Table 1 under the sectio...
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Article
Prophylaxis and treatment of GVHD: EBMT–ELN working group recommendations for a standardized practice
GVHD remains the major impediment to broader application of allogeneic haematopoietic SCT. It can be prevented completely, but at the expense of other complications, rejection, relapse or delayed immune recons...
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Article
Efficacy of exercise training in SCT patients-who benefits most?
Patients undergoing allo-HCT often experience a substantial loss in physical performance. We have recently published the general effectiveness of an exercise intervention in 105 allo-HCT patients on physical p...
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Article
Matched unrelated donor allogeneic transplantation provides comparable long-term outcome to HLA-identical sibling transplantation in relapsed diffuse large B-cell lymphoma
The objective of this retrospective analysis was to compare outcomes of patients with diffuse large B-cell lymphoma (DLBCL) who received either a matched sibling (sib) or an unrelated donor (URD) allogeneic he...