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Article
Measurement of Three-Dimensional Anisotropic Diffusion by Multiphoton Fluorescence Recovery after Photobleaching
The multiphoton fluorescence recovery after photobleaching (MP-FRAP) technique has been developed to measure the three-dimensional (3D) solute diffusion within biological systems. However, current 3D MP-FRAP m...
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Article
Open AccessAn inducible CiliaGFP mouse model for in vivo visualization and analysis of cilia in live tissue
Cilia are found on nearly every cell type in the mammalian body, and have been historically classified as either motile or immotile. Motile cilia are important for fluid and cellular movement; however, the rol...
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Article
A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma
Melanoma is the most aggressive form of skin cancer, responsible for the majority of skin cancer related deaths. Thus, the search for natural molecules which can effectively destroy tumors while promoting immu...
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Article
Anisotropic Solute Diffusion Tensor in Porcine TMJ Discs Measured by FRAP with Spatial Fourier Analysis
A new method solely based on spatial Fourier analysis (SFA) was developed to completely determine a two-dimensional (2D) anisotropic diffusion tensor in fibrous tissues using fluorescence recovery after photob...
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Article
ATP as a mediator of macula densa cell signalling
Within each nephro-vascular unit, the tubule returns to the vicinity of its own glomerulus. At this site, there are specialised tubular cells, the macula densa cells, which sense changes in tubular fluid compo...
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Article
Open AccessLoss of apical monocilia on collecting duct principal cells impairs ATP secretion across the apical cell surface and ATP-dependent and flow-induced calcium signals
Renal epithelial cells release ATP constitutively under basal conditions and release higher quantities of purine nucleotide in response to stimuli. ATP filtered at the glomerulus, secreted by epithelial cells ...
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Protocol
Confocal and Two-Photon Microscopy
The majority of renal physiological processes, including glomerular filtrate formation, tubular reabsorption and secretion, and regulation of cortical and medullary blood flow, involve the complex interaction ...
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Chapter
Role of Intracellular Calcium in the Regulation of Renal Hemodynamics
Intracellular calcium contributes to renal hemodynamic regulatory mechanisms in multiple ways. Calcium channel blockers elicit a selective vasodilation of preglomerular arterioles leading to increases in renal...
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Chapter
The Regulation of Glomerular Filtration Rate in Mammalian Kidneys
During organogenesis of the kidney, small S-shaped meta-nephric vesicles form from the undifferentiated metanephric mesoderm. The cephalic part of each primitive renal tubule in-vaginates to form a cleft withi...
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Chapter
The Regulation of Glomerular Filtration Rate in Mammalian Kidneys
During organogenesis of the kidney, small S-shaped metanephric vesicles form from the undifferentiated metanephric mesoderm. The cephalic part of each primitive renal tubule invaginates to form a cleft within ...
