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Chapter
Monoamin-Oxidase-Hemmer
Die Monoamin-Oxidase (MAO, EC 1.4.2.4; Amin: Sauerstoff-Oxidoreduktase [desaminierend]) ist ein relativ unspezifisches mitochondriales Enzym. Es metabolisiert monoaminerge Neurotransmitter (wie Adrenalin, Nora...
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Article
CGP 3466 protects dopaminergic neurons in lesion models of Parkinson's disease
The propargylamine derivative CGP 3466 (dibenzo[b,f]oxepin-10-ylmethyl-methyl-prop-2-ynyl-amine) has previously been found to exhibit neurorescuing and antiapoptotic properties in several in vitro and in vivo...
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Chapter and Conference Paper
Neurorescuing effects of the GAPDH ligand CGP 3466B
Deprenyl, used for the treatment of Parkinson’s disease, was reported to possess neurorescuing/antiapoptotic effects independent of its MAO-B inhibiting properties. It is metabolized to (-)-desmethyldeprenyl, ...
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Article
Effect of carbamazepine, oxcarbazepine and lamotrigine on the increase in extracellular glutamate elicited by veratridine in rat cortex and striatum
Lamotrigine, carbamazepine and oxcarbazepine inhibit veratrine-induced neurotransmitter release from rat brain slices in concentrations corresponding to those reached in plasma or brain in experimental animals...
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Article
Brofaromine — a review of its pharmacological properties and therapeutic use
The antidepressant activity of monoamine oxidase inhibitors has been well established for 30 years. Nevertheless, this group of compounds was handled with great care, mainly because of the interaction potentia...
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Article
A role for computer simulation in solving the riddles of autoreceptor-mediated regulation of GABA release
The autoreceptor-mediated control of GABA release was simulated on a personal computer using commercially available software (STELLATM/ITHINKTM). The experimental data to be matched were taken from previous publi...
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Article
Autoreceptor-mediated regulation of GABA release: role of uptake inhibition and effects of novel GABAB antagonists
While the role of GABAB autoreceptors in the regulation of GABA release in synaptosomes and brain slices is well established, little is known about their role in vivo. Doubts have arisen because there is an appar...
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Article
Savoxepine: striatal dopamine-D2 receptor occupancy in human volunteers measured using positron emission tomography (PET)
The extent and duration of striatal dopamine-D2 receptor occupancy by savoxepine in humans has been studied using positron emission tomography with [11C]-raclopride, in order to investigate why the anticipated fa...
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Article
Weak effects of local and systemic administration of the GABA uptake inhibitor, SK&F 89976, on extracellular GABA in the rat striatum
The effects of local and systemic administration of the potent GABA uptake inhibitor, SK&F 89976, on GABA overflow from the striatum of conscious rats were investigated in brain dialysis experiments. Administr...
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Article
Systemic administration of baclofen and the GABAB antagonist, CGP 35348, does not affect GABA, glutamate or aspartate in microdialysates of the striatum of conscious rats
Previous in vitro experiments have shown that the GABAB agonist, baclofen, and the antagonist, CGP 35348, respectively, decrease and increase the autoreceptor-mediated release of GABA in brain slices and synaptos...
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Article
CGP 28014, a new inhibitor of cerebral catechol-O-methylation with a non-catechol structure
CGP 28014 (N-(2-pyridone-6-yl)-N′,N′-di-n-propylformamidine) or its methanesulfonate salt CGP 28014 A was suspected to be a catechol-O-methyl-transferase (COMT) inhibitor because it was found to reduce the lev...
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Article
Investigations on GABAB receptor-mediated autoinhibition of GABA release
In this study, we have investigated the effects of phaclofen on the [3H] overflow from [3H]GABA prelabelled rat cortical slices and its interaction with the effects of (−)-baclofen in dependence of the stimulatio...
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Article
Release of endogenous GABA from the substantia nigra is not controlled by GABA autoreceptors
The characteristics of the release of GABA from slices of the rat substantia nigra, elicited by electrical stimulation at frequencies of 0.5–48 Hz and by elevated K+ concentrations ranging from 15–35 mmol/l, was ...
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Article
Ca2+-dependent release of endogenous GABA from rat cortical slices from different pools by different stimulation conditions
The previously reported inhibitory effect of (−)-baclofen on the electrically evoked release of endogenous GABA from rat brain slices indicated the possibility of existence of GABAB autoreceptors. In this study, ...
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Article
The measurement of the release of endogenous GABA from rat brain slices by liquid chromatography with electrochemical detection
A method for the determination of GABA by derivatization with 2,4,6-trinitrobenzenesulphonic acid and subsequent separation and quantitation by HPLC with electrochemical detection was characterized with respec...
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Chapter and Conference Paper
Basic and Clinical Aspects of the Activity of the New Monoamine Oxidase Inhibitors
The clinical relevance of the neurobiochemical and pharmacological properties of the new generation of monoamine oxidase inhibitors (MAOIs) is reviewed and discussed. The most distinctive characteristics of th...
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Book and Conference Proceedings
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Chapter and Conference Paper
Der Beitrag der Biochemie zur Psychiatrischen Forschung und Therapie
Vorstellungen über die Materie, aus welcher das Gehirn besteht, und welchen Änderungen sie während dessen Funktion unterworfen sein könnte, gab es natürlich schon früh in der Geschichte der Menschheit, und im ...
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Chapter
Urinary Excretion of Tryptamine, MHPG, HVA, VMA, and HIAA by Volunteers treated with CGP 4718, a combined inhibitor of MAO-A and 5-HT Uptake
The new substance CGP 4718 A (4-(5-chloro-2-benzofuranyl)-1-methylpiperidine hydrochloride) in animal experiments shows both 5-HT-uptake blocking and (preferentially) MAO-A inhibiting properties. CGP 4718 A wa...
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Chapter
Cerebral 2-Phenylethylamine Concentrations and Turnover not Influenced by Various Pharmacological Treatments in Rats
2-Phenylethylamine (PEA), a compound with stimulant properties when administered to animals, occurs in minute quantities in the normal mammalian brain (Durden et al. 1973). The turnover of this amine is high (...
