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Article
Quality of life in the Danish general population – normative data and validity of WHOQOL-BREF using Rasch and item response theory models
Background: The main objective of this study was to investigate the construct validity of the WHOQOL-BREF by use of Rasch and Item Response Theory models and to examine the stability of the model across high/low...
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Chapter
Quality of Life and Rating Scales of Depression
Rating scales for depression can be considered as the quantification of the symptoms included in the DSM-IV diagnosis of major depression. Among the essential psychometric properties of depression rating scale...
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Article
Open AccessNeurobiological and psychological correlates of suicidal attempts and thoughts of death in patients with major depression
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Article
Open AccessReliability, validity and psychometric properties of the Greek translation of the Major Depression Inventory
The Major Depression Inventory (MDI) is a brief self-rating scale for the assessment of depression. It is reported to be valid because it is based on the universe of symptoms of DSM-IV and ICD-10 depression. T...
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Article
Citalopram dose-response revisited using an alternative psychometric approach to evaluate clinical effects of four fixed citalopram doses compared to placebo in patients with major depression
Rationale. Among the many problems in interpreting dose-response studies with antidepressants are the psychometric problems in the identification of true antidepressive effect versus true adverse...
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Article
Post-stroke depression: combined treatment with imipramine or desipramine and mianserin
In a 6-week study the efficacy of combined treatment of imipramine plus mianserin was compared to combined treatment of desipramine plus mianserin in patients with post-stroke depression. Patients were require...
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Chapter and Conference Paper
The PCASEE Model: An Approach to Subjective Well-Being
There are many ways to measure the functional state of an individual, and the number of proposals for scales purported to measure quality of life is growing at a fast rate. This indicates that few of the exist...
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Chapter and Conference Paper
Therapeutic Potentials of Recently Introduced Antidepressants
Antidepressant drugs have not been classified very systematically and no commonly accepted nomenclature has been developed. Classification has been based upon criteria as different as the time of development o...
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Article
Issues of concern in the standardization and harmonization of drug trials in Europe: health-related quality of life, ESCT meeting, Strasbourg, 23–24 May 1991
Overviews of the development of the concept of quality of life from a medical viewpoint, and the need for new models and methods to assess health-related quality of life were presented, along with WHO, FDA and...
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Article
Self- and observer assessment in anxiolytic drug trials: A comparison of their validity
Self-rating scales are considered to be less useful for comparing different treatments in anxiety patients than observer-rating scales. However, the empirical evidence for this assumption is not adequate. A se...
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Article
Bromazepam in generalized anxiety
Bromazepam was compared with placebo and with chlorprothixene in a randomized, double-blind group-comparative multicenter trial in general practice. Two hundred and forty-five patients with generalized anxiety...
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Chapter and Conference Paper
Psychometric Developments of the Hamilton Scales: The Spectrum of Depression, Dysthymia, and Anxiety
The history of mental rating scales begins with the intelligence scales developed by Binet (1903). As stated by Terman and Merrill (1957): “…the Binet type of scales has no serious rival. It is not merely an i...
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Chapter and Conference Paper
Methodological Problems in Assessing Quality of Life as Outcome in Psychopharmacology: A Multiaxial Approach
Clinical research into quality of life has increased intensively since 1964, when this concept was introduced (Bech 1987a). In medicine, quality of life has been analysed especially in clinical trials of cardi...
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Chapter and Conference Paper
Measuring the Efficacy of Psychotropic Drugs: Clinical Symptoms and Rating Scales
The pathophysiology of anxiety, affective and schizophrenic disorders is not known. Therefore the efficacy of psychotropic drugs cannot be tested by their effect on the pathophysiology of mental disorders. The...
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Article
Clomipramine and mianserin in chronic idiopathic pain syndrome
The reduction of pain by two antidepressants, clomipramine and mianserin, was, in this study on 253 patients with chronic idiopathic pain syndrome, found to be not better than a placebo when all patients were ...
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Chapter
Diagnostic Dimensions of the Newcastle Scales and the Response to Antidepressant Treatments
During the last decades when many new antidepressants have been evaluated against such reference drugs as imipramine and amitriptyline, rating scales measuring the severity of depressive states have had much m...
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Chapter and Conference Paper
Clinical Effects of Selective Serotonin Reuptake Inhibitors
Meta-analysis of controlled clinical trials has recently been established as a discipline that critically reviews and statistically combines the results of new treatment modalities. The objectives of a meta-an...
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Chapter and Conference Paper
Angst und Depression: Erfassung körperlicher und psychischer Aspekte mittels der Hamilton-Skalen
Die getrennte Erfassung von Angst und Depression erscheint in der psychopharmakologischen Evaluationsforschung wünschenswert, stößt jedoch auf methodische Schwierigkeiten (Maier et al. 1984). Die Symptomatik d...
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Article
Steady-state concentrations of imipramine and its metabolites in relation to the sparteine/debrisoquine polymorphism
Thirty-five imipramine treated patients were phenotyped with regard to polymorphic drug oxidation using sparteine and/or debrisoquine.
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Article
Steady-state levels of imipramine and its metabolites: Significance of dose-dependent kinetics
Seventeen hospitalized patients (age 39–66 years), received a loading dose of 100 mg imipramine HCl and then 50 mg b.i.d. The 12-h plasma concentration at steady-state varied between 40–637 nmol/l for imiprami...
