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  1. No Access

    Chapter and Conference Paper

    Triggering and Amplification

    The molecular events which link photon absorption to membrane conductance changes in photoreceptor cells begin with light activation of rhodopsin. In vertebrates, activated rhodopsin (Rh*) triggers an enzymati...

    M. L. Applebury, P. A. Liebman, M. Chabre… in The Molecular Mechanism of Photoreception (1986)

  2. No Access

    Chapter and Conference Paper

    Control of Visual Receptor Cyclic GMP and Visual Excitation

    Psychophysical measurements have shown that human rods can detect single photons (Hecht et al, 1942). More recent electrophysiological recordings have demonstrated single photon responses (quantum bumps) in am...

    P. A. Liebman in Molecular and Cellular Basis of Visual Acuity (1984)

  3. No Access

    Article

    Acid polysaccharide content of frog rod outer segments determined by metachromatic toluidine blue staining

    Sulfonation of periodate-oxidized vicinal hydroxyl groups on a polysaccharide backbone allows binding of toluidine blue (aldehyde bisulfite-toluidine blue or ABT staining) with a concurrent metachromatic shift...

    R. E. Drzymala, P. A. Liebman, G. Romhanyi in Histochemistry (1982)

  4. No Access

    Article

    ATP mediates rapid reversal of cyclic GMP phosphodiesterase activation in visual receptor membranes

    Weak or strong lights will activate visual receptor rod disk membrane (RDM) cyclic GMP phosphodiesterase (PDE) In the presence of GTP cofactor1,2. A similarly activated GTPase can exhaust small amounts of initial...

    P. A. Liebman, E. N. Pugh Jr in Nature (1980)

  5. No Access

    Article

    Super dense carotenoid spectra resolved in single cone oil droplets

    CONE visual receptors in reptiles and birds contain brilliant yellow, orange or red oil droplets, 3–6 µm in diameter, through which light must pass before reaching the visual pigment. The possible role of thes...

    P. A. LIEBMAN, A. M. GRANDA in Nature (1975)

  6. No Access

    Article

    Membrane structure changes in rod outer segments associated with rhodopsin bleaching

    Static and time resolved birefringence analysis used to quantitate a fast membrane structure change driven by the formation of metarhodopsin II in intact frog retina. This change can be accounted for by the di...

    P. A. Liebman, W. S. Jagger, M. W. Kaplan, F. G. Bargoot in Nature (1974)

  7. No Access

    Chapter and Conference Paper

    Microspectrophotometry of Visual Receptors

    During this brief talk, I would like to try to give an updated view, since my Handbook review (1) written in 1969 of the kinds of things I believe microspectrophotometry (MSP) of single vertebrate receptor out...

    P. A. Liebman in Biochemistry and Physiology of Visual Pigments (1973)

  8. No Access

    Book

    Photochemistry of Vision

    Herbert J. A. Dartnall in Handbook of Sensory Physiology (1972)

  9. No Access

    Chapter

    Microspectrophotometry of Photoreceptors

    In nearly thirty intervening years we have not overcome the exasperation so poetically expressed by Gordon Walls, for in achieving the conditions of illumination under which our own cones “see” color, the impo...

    P. A. Liebman in Photochemistry of Vision (1972)

  10. No Access

    Article

    Autofluorescence of Visual Receptors

    SINCE 1878 when Kühne reported the faint bluish fluorescence of the dark adapted retina and its brighter greenish supplementation when the visual pigments were bleached1, these observations have been little used ...

    P. A. LIEBMAN, R. A. LEIGH in Nature (1969)