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  1. Article

    Open Access

    Correction: Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    H.-L. Huang, H.-Y. Wu, P.-C. Chu, I.-L. Lai, P.-H. Huang, S. K. Kulp… in Oncogenesis (2020)

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  2. Article

    Open Access

    Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells

    MUC1-C overexpression has been associated with the progression of pancreatic tumors by promoting the aggressive and metastatic phenotypes. As MUC1 is a STAT3 target gene, STAT3 plays a major role in regulating MU...

    H-L Huang, H-Y Wu, P-C Chu, I-L Lai, P-H Huang, S K Kulp, S-L Pan, C-M Teng… in Oncogenesis (2017)

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  3. No Access

    Article

    TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

    The highly homeostasis-resistant nature of cancer cells leads to their escape from treatment and to liver metastasis, which in turn makes pancreatic ductal adenocarcinoma (PDAC) difficult to treat, especially ...

    P-H Huang, P-J Lu, L-Y Ding, P-C Chu, W-Y Hsu, C-S Chen, C-C Tsao, B-H Chen… in Oncogene (2017)

  4. No Access

    Article

    Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells

    Integrin-linked kinase (ILK) is a mediator of aggressive phenotype in pancreatic cancer. On the basis of our finding that knockdown of either KRAS or ILK has a reciprocal effect on the other’s expression, we h...

    P-C Chu, M-C Yang, S K Kulp, S B Salunke, L E Himmel, C-S Fang, A M Jadhav… in Oncogene (2016)

  5. Article

    Open Access

    PHRF1 promotes genome integrity by modulating non-homologous end-joining

    Methylated histone readers are critical for chromatin dynamics, transcription, and DNA repair. Human PHRF1 contains a plant homeodomain (PHD) that recognizes methylated histones and a RING domain, which ubiqui...

    C-F Chang, P-C Chu, P-Y Wu, M-Y Yu, J-Y Lee, M-D Tsai, M-S Chang in Cell Death & Disease (2015)

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  6. No Access

    Chapter and Conference Paper

    Numerical Wave Modeling and Wave Energy Estimation

    In a rapidly evolving operational and research framework concerning the global energy resources, new frontiers have been set for the scientific community working on environmental and renewable energy issues. I...

    G. Galanis, G. Zodiatis, D. Hayes… in Advances in Meteorology, Climatology and A… (2013)

  7. No Access

    Chapter and Conference Paper

    Investigation of the Effect of Acoustic Pressure and Sonication Duration on Focused-Ultrasound Induced Blood-Brain Barrier Disruption

    The purpose of this study is to investigate the influence of the ultrasound peak pressure and sonication duration on blood-brain barrier (BBB) disruption, and also seek for the optimized sonication parameter t...

    P. C. Chu, M. C. Hsiao, Y. H. Yang… in 13th International Conference on Biomedica… (2009)

  8. No Access

    Article

    Constraint Handling in Genetic Algorithms: The Set Partitioning Problem

    In this paper we present a genetic algorithm-based heuristic for solving the set partitioning problem (SPP). The SPP is an important combinatorial optimisation problem used by many airlines as a mathematical m...

    P.C. Chu, J.E. Beasley in Journal of Heuristics (1998)

  9. No Access

    Article

    A Genetic Algorithm for the Multidimensional Knapsack Problem

    In this paper we present a heuristic based upon genetic algorithms for the multidimensional knapsack problem. A heuristic operator which utilises problem-specific knowledge is incorporated into the standard ge...

    P.C. Chu, J.E. Beasley in Journal of Heuristics (1998)

  10. No Access

    Article

    Effects of convection instability due to incompatibility between ocean dynamics and surface forcings

    The study demonstrates that an incompatibility between a surface temperature climatology and a given ocean model, into which the climatology is assimilated via Haney restoration, can cause model ocean climate ...

    W. Cai, P. C. Chu in Annales Geophysicae (1997)

  11. No Access

    Article

    Thermodynamic feedback between clouds and the ocean surface mixed layer

    A cloud—ocean planetary boundary layer (OPBL) feedback mechanism is presented and tested in this paper. Water vapor, evaporated from the ocean surface or transported by the large—scale air flow, often forms co...

    P. C. Chu, Roland W. Garwood in Advances in Atmospheric Sciences (1990)

  12. No Access

    Article

    Relationship between thermally forced surface wind and sea surface temperature gradient

    An important part of the influence of the oceans on the atmosphere is through direct radiation, sensible heat flux and release of latent heat of evaporation, whereby all of these processes are directly related...

    P. C. Chu in pure and applied geophysics (1989)

  13. No Access

    Article

    An instability theory of air-sea interaction for coastal upwelling

    A surface wind (seabreeze), thermally generated by differential sea surface temperature, is introduced to Gill-Clarke’s model (1974) through wind stress for investigating the effects of seabreeze on coastal up...

    P. C. Chu in Advances in Atmospheric Sciences (1988)