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  1. No Access

    Article

    FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway

    A significant challenge in the post-genomic era is how to prioritize differentially expressed and uncharacterized novel genes found in hepatocellular carcinoma (HCC) microarray profiling. One such category is ...

    C-H Chen, P-J Lu, Y-C Chen, S-L Fu, K-J Wu, A-P Tsou, Y-C G Lee, T-C E Lin… in Oncogene (2007)

  2. No Access

    Article

    Microwave irradiation enhances gene and oligonucleotide delivery and induces effective exon skip** in myoblasts

    Microwave (MW) energy consists of electric and magnetic fields and is able to penetrate deep into biological materials. We investigated the effect of MW (2450 MHz) irradiation on gene delivery in cultured mous...

    T J Doran, P J Lu, G S Vanier, M J Collins, B Wu, Q L Lu in Gene Therapy (2009)

  3. No Access

    Article

    MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation

    MicroRNAs (miRNAs) make up a novel class of gene regulators; they function as oncogenes or tumor suppressors by targeting tumor-suppressor genes or oncogenes. A recent study that analysed a large number of hum...

    K-H Lee, Y-L Chen, S-D Yeh, M Hsiao, J-T Lin, Y-G Goan, P-J Lu in Oncogene (2009)

  4. No Access

    Article

    TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer

    We integrated four gene expression profile data sets, namely two different pair-matched stage I lung adenocarcinoma data sets, secondary metastatic tumors vs benign tumors and lung tumor metastasizes to the br...

    M-C Shih, J-Y Chen, Y-C Wu, Y-H Jan, B-M Yang, P-J Lu, H-C Cheng, M-S Huang… in Oncogene (2012)

  5. No Access

    Article

    RUNX3-mediated transcriptional inhibition of Akt suppresses tumorigenesis of human gastric cancer cells

    Activation of Akt signaling pathway has been suggested involving in chemoresistance, metastasis and tumorigenesis of gastric cancer. However, the mechanism of Akt regulation in gastric cancer is not fully unde...

    F-C Lin, Y-P Liu, C-H Lai, Y-S Shan, H-C Cheng, P-I Hsu, C-H Lee, Y-C Lee… in Oncogene (2012)

  6. No Access

    Article

    Endoplasmic reticulum ribosome-binding protein 1 (RRBP1) overexpression is frequently found in lung cancer patients and alleviates intracellular stress-induced apoptosis through the enhancement of GRP78

    Lung cancer is the leading cause of cancer deaths and is the most occurring malignancy worldwide. Unraveling the molecular mechanisms involved in lung tumorigenesis will greatly improve therapy. During early t...

    H-Y Tsai, Y-F Yang, A T Wu, C-J Yang, Y-P Liu, Y-H Jan, C-H Lee, Y-W Hsiao… in Oncogene (2013)

  7. Article

    Open Access

    MicroRNA-18a is elevated in prostate cancer and promotes tumorigenesis through suppressing STK4 in vitro and in vivo

    MicroRNAs (miRNAs) comprise a class of short, non-coding RNAs that regulate protein synthesis through posttranscriptional modifications. In this study, we found significant upregulation of miR-18a in prostate ...

    T-I Hsu, C-H Hsu, K-H Lee, J-T Lin, C-S Chen, K-C Chang, C-YJ Su, M Hsiao… in Oncogenesis (2014)

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  8. No Access

    Article

    TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

    The highly homeostasis-resistant nature of cancer cells leads to their escape from treatment and to liver metastasis, which in turn makes pancreatic ductal adenocarcinoma (PDAC) difficult to treat, especially ...

    P-H Huang, P-J Lu, L-Y Ding, P-C Chu, W-Y Hsu, C-S Chen, C-C Tsao, B-H Chen… in Oncogene (2017)