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  1. Article

    Open Access

    Sublinear scaling of the cellular proteome with ploidy

    Ploidy changes are frequent in nature and contribute to evolution, functional specialization and tumorigenesis. Analysis of model organisms of different ploidies revealed that increased ploidy leads to an incr...

    G. Yahya, P. Menges, P. S. Amponsah, D. A. Ngandiri, D. Schulz… in Nature Communications (2022)

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  2. Article

    Hidradenitis suppurativa/Acne inversa – operative Optionen, Rekonstruktionen und Kombinationen mit medikamentösen Therapien – Ein Update

    Hidradenitis suppurativa/Acne inversa (HS/AI) ist eine chronisch-entzündliche Hauterkrankung, deren Behandlung sowohl konservative als auch chirurgische Behandlungsmöglichkeiten umfasst. In den Hurley-Stadien ...

    P. Cramer, S. Schneider-Burrus, M. Kovács, L. Scholl, M. Podda… in Der Hautarzt (2021)

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  3. No Access

    Article

    Richter transformation in chronic lymphocytic leukemia (CLL)—a pooled analysis of German CLL Study Group (GCLLSG) front line treatment trials

    Richter transformation (RT) is defined as development of aggressive lymphoma in patients (pts) with CLL. The incidence rates of RT among pts with CLL range from 2 to 10%. The aim of this analysis is to report ...

    O. Al-Sawaf, S. Robrecht, J. Bahlo, A. M. Fink, P. Cramer, J. v Tresckow… in Leukemia (2021)

  4. Article

    Open Access

    Updated results from the phase 3 HELIOS study of ibrutinib, bendamustine, and rituximab in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma

    We report follow-up results from the randomized, placebo-controlled, phase 3 HELIOS trial of ibrutinib+bendamustine and rituximab (BR) for previously treated chronic lymphocytic leukemia (CLL)/small lymphocyti...

    G. Fraser, P. Cramer, F. Demirkan, R. Santucci Silva, S. Grosicki, A. Pristupa… in Leukemia (2019)

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  5. No Access

    Article

    Structures of transcription pre-initiation complex with TFIIH and Mediator

    For the initiation of transcription, RNA polymerase II (Pol II) assembles with general transcription factors on promoter DNA to form the pre-initiation complex (PIC). Here we report cryo-electron microscopy st...

    S. Schilbach, M. Hantsche, D. Tegunov, C. Dienemann, C. Wigge, H. Urlaub… in Nature (2017)

  6. No Access

    Article

    Impact of gender on outcome after chemoimmunotherapy in patients with chronic lymphocytic leukemia: a meta-analysis by the German CLL study group

    O Al-Sawaf, S Robrecht, J Bahlo, A M Fink, P Cramer, J von Tresckow, C Maurer… in Leukemia (2017)

  7. No Access

    Article

    Effect of first-line treatment on second primary malignancies and Richter’s transformation in patients with CLL

    This study aimed to assess the frequency of and the contributing factors for second primary malignancies (SPMs) and Richter’s transformations (RTs) following first-line treatment of chronic lymphocytic leukemi...

    C Maurer, P Langerbeins, J Bahlo, P Cramer, A M Fink, N Pflug, A Engelke… in Leukemia (2016)

  8. No Access

    Article

    Transcription initiation complex structures elucidate DNA opening

    Transcription of eukaryotic protein-coding genes begins with assembly of the RNA polymerase (Pol) II initiation complex and promoter DNA opening. Here we report cryo-electron microscopy (cryo-EM) structures of...

    C. Plaschka, M. Hantsche, C. Dienemann, C. Burzinski, J. Plitzko, P. Cramer in Nature (2016)

  9. No Access

    Article

    Architecture of the RNA polymerase II–Mediator core initiation complex

    The conserved co-activator complex Mediator enables regulated transcription initiation by RNA polymerase (Pol) II. Here we reconstitute an active 15-subunit core Mediator (cMed) comprising all essential Mediat...

    C. Plaschka, L. Larivière, L. Wenzeck, M. Seizl, M. Hemann, D. Tegunov… in Nature (2015)

  10. No Access

    Article

    Dilemma voor de verzekeringsarts: Het geheim van de cliënt?

    De heer Frederiksen is werkzaam als advocaat op een middelgroot advocaten kantoor in een niet al te grote stad in het westen van het land. Hij is al bijna twee jaar ziek thuis. Hij is in 2004 ziek geworden met...

    P. Cramer, N. H. Th. Croon, W. Koek in TBV – Tijdschrift voor Bedrijfs- en Verzek… (2007)

  11. Article

    Bladder-neck opening test in spinal cord injury patients using a new i.v. alpha-blocking agent, alfuzosin

    A bladder-neck opening test using alfuzosin, a new alpha-adrenoceptor blocking agent, was carried out in 21 patients with spinal cord injury. The efficacy of alfuzosin was assessed with 4 simple urodynamic par...

    P Cramer, E Neveux, F Régnier, J Depassio, E Bérard in Spinal Cord (1989)

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  12. No Access

    Chapter

    Chemotherapy plus radiotherapy in Clinical Stage IA to IIIB Hodgkin’s disease. Results of the H 77 trial (1977–1980)

    Major progress in the treatment of Hodgkin’s disease (HD) had been accomplished by the late sixties. Kaplan et al. at Stanford University found that when a very careful staging laparotomy with splenectomy is p...

    J. M. Andrieu, Y. Coscas, P. Cramer… in Malignant Lymphomas and Hodgkin’s Disease:… (1985)

  13. No Access

    Chapter and Conference Paper

    Die alkalische Dünndarmphosphatase im Stuhl — ein Parameter der aktuellen Schädigung der Dünndarmschleimhaut

    Die alkalische Phosphatase (AP) des menschlichen Dünndarms (D-AP) ist im Bürstensaum lokalisiert und wird infolge der kontinuierlichen Regeneration dieser Zellen in hoher Konzentration im menschlichen Stuhl au...

    F.-G. Lehmann, P. Cramer, U. Hillert… in Verhandlungen der Deutschen Gesellschaft f… (1980)

  14. No Access

    Chapter and Conference Paper

    Immunologische Differenzierung alkalischer Phosphatasen: Bestimmung der Dünndarm-, Leber- und Tumorphosphatase in Serum und Stuhl

    Die organspezifische Differenzierung der in multiplen molekularen Formen im menschlichen Serum und Stuhl vorkommenden alkalischen Phosphatasen ist ein bisher ungelöstes Problem der Routinediagnostik. Semiquant...

    F.-G. Lehmann, P. Cramer, W. R. Zengel in Verhandlungen der Deutschen Gesellschaft f… (1976)