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  1. No Access

    Article

    Antiviral potency of lupane and oleanane alkynyl-derivatives against human cytomegalovirus and papillomavirus

    A library of 18 structurally diverse semisynthetic lupane, oleanane, and ursane types triterpenoids, including C19- or C28-(1,2,3-triazolyl)- and aminomethylated derivatives obtained by the «click» reaction wi...

    Elmira F. Khusnutdinova, Anastasiya V. Petrova… in The Journal of Antibiotics (2024)

  2. No Access

    Article

    Synthesis, Cytotoxicity, and α-glucosidase Inhibitory Activity of Triterpenic and Sitosterol Tetrazole Derivatives

    A series of new triterpenic and sitosterol derivatives containing 1,2,3,4-(tetrazol-5-yl)ethoxy and -ethoxyimine fragments at positions C-2, C-3, and C-12 have been synthesized by 1,3-dipolar cycloaddition of ...

    Anastasiya V. Petrova, Alexander I. Poptsov… in Chemistry of Heterocyclic Compounds (2021)

  3. No Access

    Article

    Evaluation of cholinesterase inhibitory activity and cytotoxicity of synthetic derivatives of di- and triterpene metabolites from Pinus silvestris and Dipterocarpus alatus resins

    A series of hydroxy-, oximino-, lactame, arylidene, N-methylpiperazinyl amide, isoxazole, pyrimidine derivatives of dipterocarpol, quinopimaric, and dammarenolic acids were synthesized and evaluated for cholin...

    Irina E. Smirnova, Oxana B. Kazakova, Anne Loesche… in Medicinal Chemistry Research (2020)

  4. No Access

    Article

    Synthesis, evaluation of cytotoxicity, and antimicrobial activity of A-azepano- and A-seco-3-amino-C28-aminolupanes

    A series of new C28-amino-lupanes bearing A-azepano- and A-seco-3-amino-fragments was synthesized from 3,28-dioximino-betulin and evaluated for cytotoxicity toward the NCI-60 cancer cell line panel and antimic...

    Oxana B. Kazakova, Tatyana V. Lopatina, Irina P. Baikova… in Medicinal Chemistry Research (2020)

  5. No Access

    Article

    Synthesis of dammarenolic acid derivatives with a potent α-glucosidase inhibitory activity

    Dammarenolic acid (DA) is an A-seco-dammarane triterpenoids, isolated from Dipterocarpus alatus resin. DA was modified including reactions of esterification and amination with heterocyclic amines and l-amino acid...

    Irina E. Smirnova, Anastasiya V. Petrova, Oxana B. Kazakova… in Medicinal Chemistry Research (2020)

  6. No Access

    Article

    Synthesis and evaluation of 2,3-indolotriterpenoids as new α-glucosidase inhibitors

    A series of ring-A fused heterocycles of lupane, oleanane, ursane and dammarane triterpenoids were synthesized and evaluated for their inhibitory activity against α-glucosidase. An influence of the different t...

    Elmira F. Khusnutdinova, Irina E. Smirnova… in Medicinal Chemistry Research (2017)

  7. No Access

    Article

    Synthesis and anticancer activity of aminopropoxytriterpenoids

    Triterpenoids with aminopropoxy groups in C-28 or C-3 and C-28 positions were synthesized from betulin, erythrodiol, uvaol, oleantriol and betulinic acid N-methylpiperazinylamide by cyanoethylation and the follow...

    Gulnara V. Giniyatyllina, Irina E. Smirnova… in Medicinal Chemistry Research (2015)

  8. No Access

    Article

    Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

    A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been...

    Irina E. Smirnova, Oxana B. Kazakova, Do Quoc Viet… in Medicinal Chemistry Research (2015)