6 Result(s)
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Oscar L. Rodriguez
Biomedicine
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Article
Open AccessAuthor Correction: Vaccination induces broadly neutralizing antibody precursors to HIV gp41
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Article
Open AccessResolving haplotype variation and complex genetic architecture in the human immunoglobulin kappa chain locus in individuals of diverse ancestry
Immunoglobulins (IGs), critical components of the human immune system, are composed of heavy and light protein chains encoded at three genomic loci. The IG Kappa (IGK) chain locus consists of two large, invert...
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Article
Open AccessVaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies (bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic diversity is the design of primin...
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Article
Looking to the future of antibody genetics: resolving the roles of immunoglobulin diversity in gene regulation, function, and immunity
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Article
Characterization of the immunoglobulin lambda chain locus from diverse populations reveals extensive genetic variation
Immunoglobulins (IGs), crucial components of the adaptive immune system, are encoded by three genomic loci. However, the complexity of the IG loci severely limits the effective use of short read sequencing, li...
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Article
Open AccessT cell receptor beta germline variability is revealed by inference from repertoire data
T and B cell receptor (TCR, BCR) repertoires constitute the foundation of adaptive immunity. Adaptive immune receptor repertoire sequencing (AIRR-seq) is a common approach to study immune system dynamics. Unde...
