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Article
Open AccessMicroRNAs secreted by human preimplantation embryos and IVF outcome
To generate an effective embryo prediction model and identify a non-invasive evaluation method by analyzing microRNAs (miRNAs) in embryo culture medium.
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Article
Open AccessEvaluation of intracellular processes in quinolinic acid-induced brain damage by imaging reactive oxygen species generation and mitochondrial complex I activity
Our study aimed to elucidate the intracellular processes associated with quinolinic acid (QA)-induced brain injury by acquiring semiquantitative fluorescent images of reactive oxygen species (ROS) generation a...
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Article
Soluble CLEC-2 is generated independently of ADAM10 and is increased in plasma in acute coronary syndrome: comparison with soluble GPVI
Soluble forms of platelet membrane proteins are released upon platelet activation. We previously reported that soluble C-type lectin-like receptor 2 (sCLEC-2) is released as a shed fragment (Shed CLEC-2) or as...
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Article
Open AccessSensitive and early detection of mitochondrial dysfunction in the liver of NASH model mice by PET imaging with 18F-BCPP-BF
Nonalcoholic fatty liver disease is a common disorder that progresses from simple fatty liver (steatosis) to nonalcoholic steatohepatitis (NASH). It is thought that mitochondrial dysfunction plays a critical r...
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Article
Open AccessFactors affecting pregnancy outcomes in young women treated with fertility-preserving therapy for well-differentiated endometrial cancer or atypical endometrial hyperplasia
Patients ho** to preserve their fertility receive conservative treatment with high-dose medroxyprogesterone acetate (MPA) for well-differentiated endometrioid adenocarcinoma (EC) or atypical endometrial hype...
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Article
Open AccessImaging of reactive oxygen species using [3H]hydromethidine in mice with cisplatin-induced nephrotoxicity
Reactive oxygen species (ROS) have been implicated in cisplatin-induced nephrotoxicity. The aim of this study was to investigate the potential of using [3H]-labeled N-methyl-2,3-diamino-6-phenyl-dihydrophenanthri...
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Article
Open AccessImaging of reactive oxygen species in focal ischemic mouse brain using a radical trap** tracer [3H]hydromethidine
Reactive oxygen species (ROS) have been implicated in the pathophysiology of the brain after ischemic stroke. In this study, we investigate the generation of brain ROS after transient focal ischemia in mice us...
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Article
Open AccessSuccessful implantation after reducing matrix metalloproteinase activity in the uterine cavity
Recently, the concept of recurrent implantation failure (RIF) in assisted reproductive technology has been enlarged. Chronic uterine inflammation is a known cause of implantation failure and is associated with...
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Article
Determination of Histamine in Rat Plasma and Tissue Extracts by Intramolecular Excimer-Forming Derivatization and LC with Fluorescence Detection
A highly sensitive and selective method for determination of histamine in rat plasma and tissue extracts by liquid chromatography with fluorescence detection is described. The method is based on precolumn deri...
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Article
De-coupling of blood flow and metabolism in the rat brain induced by glutamate
Glutamate plays an essential role in neuronal cell death in many neurological disorders. In this study, we examined both glucose metabolism and cerebral blood flow in the same rat following infusion of glutama...
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Article
Role of NMDA receptor upon [14C]acetate uptake into intact rat brain
To clarify the role of N-methyl-d-aspartate (NMDA) receptors upon [14C]acetate uptake in the rodent central nervous system (CNS), ibotenic acid (IBO) was infused into the right striatum of the rat brain.
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Article
Evaluation of biomarkers of occupational exposure to toluene at low levels
The purpose of the present study was to compare validity of various biomarkers of occupational exposure to toluene (Tol) at low levels. The focus was placed on the comparison of un-metabolized toluene in urine...
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Article
Comparative evaluation of biomarkers of occupational exposure to toluene
This study was initiated to make comparative evaluation of five proposed urinary markers of occupational exposure to toluene, i.e., benzyl alcohol, benzylmercapturic acid, o-cresol, hippuric acid and un-metaboliz...
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Article
Glial metabolic dysfunction caused neural damage by short-term ischemia in brain
Although several pieces of evidence have indicated that glial cells support neuronal cells in the ischemia-reperfusion brain, the direct contribution of glial cells to cell damage is not well known. The presen...
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Article
Distinct different intra-tumor distribution of FDG between early phase and late phase in mouse fibrosarcoma
An early image of intra-tumor distribution of14C-labeled fluorodeoxy glucose (14C-FDG) was compared with a late image of18F-labeled FDG (18F-FDG) using mouse fibrosarcoma. Heterogeneous intra-tumor distribution o...
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Article
Binding kinetics of11c-n-methyl piperidyl benzilate (11c-nmpb) in a rhesus monkey brain using the cerebellum as a reference region
The binding kinetics of11C-N-methyl piperidyl benzilate (11C-NMPB) in rhesus monkey brain were studied using animal positron emission tomography (PET) (SHR2000). This study is intended to assess the validity of t...
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Article
Effects of anesthesia upon18F-FDG uptake in rhesus monkey brains
The kinetics of18F-fluorodeoxyglucose (18F-FDG) in the monkey brain were monitored, and comparisons were made between the conscious state and when under ketamine and pentobarbital anesthesia. Rhesus monkeys were ...
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Article
Effect of rolipram on relative 14C-deoxyglucose uptake in inflammatory lesions and skeletal muscle
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) has become a useful imaging tool for inflammatory diseases. In this study we investigated the effects of rolipram, a selective phosphodiesterase ty....
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Article
Simultaneous Determination of Serotonin and 5-Hydroxyindole-3-acetic Acid in Human Urine by Automated Precolumn Derivatization and Semi-microbore Column Liquid Chromatography with Fluorescence Detection
An improved high-performance liquid-chromatographic (HPLC) assay for the simultaneous determination of serotonin (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) in human urine is reported. Following the auto...
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Article
Ionic interaction of [11C]-N, α-dimethylbenzylamine (DMBA) in rodent brain
The [S] enantiomer of [11C]-N,α-dimethylbenzylamine (DMBA) was synthesized by N-methylation of [S]-α-methylbenzylamine, and its biodistribution in mice was measured. [11C]-[S]-DMBA was rapidly distributed into th...
