-
Article
Open AccessMild COVID-19 has no detrimental effect on semen quality
As of today, the effect of coronavirus disease 2019 (COVID-19) on male fertility remains unclear. Studies published so far have partly contradictory results, likely due to very small sample sizes and heterogen...
-
Protocol
Infection of 3D Brain Organoids with Human Pathogenic Viruses Under Biosafety Level-3 Conditions with Subsequent Inactivation to Study Viral Replication, Pathomechanisms, and Other Viral Infection-Mediated Effects
Viral infectious diseases may cause neurological symptoms primarily in two nonexclusive ways. Infection may lead to an excessive inflammatory response that damages the neuronal system, which is referred to as ...
-
Article
Open AccessPrognostic markers for the clinical course in the blood of patients with SARS-CoV-2 infection
The presentation of peptides and the subsequent immune response depend on the MHC characteristics and influence the specificity of the immune response. Several studies have found an association between HLA var...
-
Article
Open AccessRespiratory viruses dynamics and interactions: ten years of surveillance in central Europe
Lower respiratory tract infections are among the main causes of death. Although there are many respiratory viruses, diagnostic efforts are focused mainly on influenza. The Respiratory Viruses Network (RespVir)...
-
Article
Open AccessHigh rate of clinically unrecognized SARS-CoV-2 infections in pediatric palliative care patients
Little is known about the frequency and clinical course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in pediatric patients with severe comorbidities. In this prospective cross-sec...
-
Article
Open AccessAssociation of HLA genotypes, AB0 blood type and chemokine receptor 5 mutant CD195 with the clinical course of COVID-19
COVID-19, the pandemic disease caused by infection with SARS-CoV-2, may take highly variable clinical courses, ranging from symptom-free and pauci-symptomatic to fatal disease. The goal of the current study wa...
-
Article
Open AccessRhinovirus prevalence as indicator for efficacy of measures against SARS-CoV-2
Non-pharmaceutical measures to control the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) should be carefully tuned as they can impose a heavy social and economic burden. To quantify an...
-
Article
Open AccessSensitivity of anti-SARS-CoV-2 serological assays in a high-prevalence setting
Evaluation and power of seroprevalence studies depend on the performed serological assays. The aim of this study was to assess four commercial serological tests from EUROIMMUN, DiaSorin, Abbott, and Roche as w...
-
Article
Open AccessMeningitis gone viral: description of the echovirus wave 2013 in Germany
Aseptic meningitis epidemics may pose various health care challenges.
-
Article
Open AccessExtensive immune reconstitution inflammatory syndrome in Fingolimod-associated PML: a case report with 7 Tesla MRI data
Progressive multifocal leukoencephalopathy (PML) is a rare complication of patients treated with fingolimod.
-
Article
Detection of JC virus archetype in cerebrospinal fluid in a MS patient with dimethylfumarate treatment without lymphopenia or signs of PML
We report a 76-year-old MS patient, treated with DMF for 3 years. Lymphocytes never showed values below 1240/µl. CSF analysis revealed 1,988,880 copies/ml of JCV-DNA, JCV-DNA was detectable in serum and anti-J...
-
Article
Open AccessStrain-dependent effects of clinical echovirus 30 outbreak isolates at the blood-CSF barrier
Echovirus (E) 30 (E-30) meningitis is characterized by neuroinflammation involving immune cell pleocytosis at the protective barriers of the central nervous system (CNS). In this context, infection of the bloo...
-
Article
Open AccessHighly individual patterns of virus-immune IgG effector responses in humans
IgG responses are fundamental to adaptive immunity and document immunological memory of previous pathogen encounter. While specific antigen recognition is mediated by the variable F(ab′)2 domain of IgG, various e...
-
Article
Progressive multifocal leukoencephalopathy and immune reconstitution inflammatory syndrome (IRIS)
Progressive multifocal leukoencephalopathy is a viral encephalitis induced by the John Cunningham (JC) virus, an ubiquitous neurotropic papovavirus of the genus polyomavirus that in healthy people in latency r...
-
Article
Anti-JC virus antibodies in rituximab-treated patients with neuromyelitis optica spectrum disorder
Rituximab, a chimeric monoclonal anti-CD20 antibody, has been proposed to be effective for neuromyelitis optica spectrum disorder (NMOSD). A concern for develo** progressive multifocal leukoencephalopathy (P...
-
Article
Genetic analysis and antigenic characterization of human respiratory syncytial virus group A viruses isolated in Germany 1996–2008
The genetic and antigenic variability of 18 human respiratory syncytial virus group A viruses isolated in Germany from 1996 to 2008 was evaluated by nucleotide sequencing of the complete G and F genes and enzy...
-
Article
Open AccessRisk adapted transmission prophylaxis to prevent vertical HIV–1 transmission: Effectiveness and safety of an abbreviated regimen of postnatal oral Zidovudine
Antiretroviral drugs including zidovudine (ZDV) are effective in reducing HIV mother to child transmission (MTCT), however safety concern remains. The optimal duration of postnatal ZDV has not been established...
-
Article
Open AccessComparison of three multiplex PCR assays for the detection of respiratory viral infections: evaluation of xTAG respiratory virus panel fast assay, RespiFinder 19 assay and RespiFinder SMART 22 assay
A broad spectrum of pathogens is causative for respiratory tract infections, but symptoms are mostly similar. Therefore, the identification of the causative viruses and bacteria is only feasible using multiple...
-
Article
Erratum to: Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients
-
Article
Prevalence and characteristics of hepatitis B and C virus infections in treatment-naïve HIV-infected patients
In HIV-infected treatment-naïve patients, we analyzed risk factors for either chronic hepatitis B (HBV) infection, occult HBV infection (OHBV) or a positive hepatitis C (HCV) serostatus. A total of 918 patient...
