16 Result(s)
within
Orrin Devinsky
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessAlignment of brain embeddings and artificial contextual embeddings in natural language points to common geometric patterns
Contextual embeddings, derived from deep language models (DLMs), provide a continuous vectorial representation of language. This embedding space differs fundamentally from the symbolic representations posited ...
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Open AccessClosed-loop brain stimulation augments fear extinction in male rats
Dysregulated fear reactions can result from maladaptive processing of trauma-related memories. In post-traumatic stress disorder (PTSD) and other psychiatric disorders, dysfunctional extinction learning preven...
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Open AccessThe role of superficial and deep layers in the generation of high frequency oscillations and interictal epileptiform discharges in the human cortex
Describing intracortical laminar organization of interictal epileptiform discharges (IED) and high frequency oscillations (HFOs), also known as ripples. Defining the frequency limits of slow and fast ripples. ...
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Open AccessStructural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression
Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIG...
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Open AccessHeterogeneous nuclear ribonucleoprotein U (HNRNPU) safeguards the develo** mouse cortex
HNRNPU encodes the heterogeneous nuclear ribonucleoprotein U, which participates in RNA splicing and chromatin organization. Microdeletions in the 1q44 locus encompassing HNRNPU and other genes and point mutation...
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Open AccessImagined speech can be decoded from low- and cross-frequency intracranial EEG features
Reconstructing intended speech from neural activity using brain-computer interfaces holds great promises for people with severe speech production deficits. While decoding overt speech has progressed, decoding ...
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Open AccessLong-term priors influence visual perception through recruitment of long-range feedback
Perception results from the interplay of sensory input and prior knowledge. Despite behavioral evidence that long-term priors powerfully shape perception, the neural mechanisms underlying these interactions re...
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Open AccessMoment-by-moment tracking of naturalistic learning and its underlying hippocampo-cortical interactions
Humans form lasting memories of stimuli that were only encountered once. This naturally occurs when listening to a story, however it remains unclear how and when memories are stored and retrieved during story-...
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Open AccessiEEG-BIDS, extending the Brain Imaging Data Structure specification to human intracranial electrophysiology
The Brain Imaging Data Structure (BIDS) is a community-driven specification for organizing neuroscience data and metadata with the aim to make datasets more transparent, reusable, and reproducible. Intracrania...
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Article
Open AccessHippocampal gamma predicts associative memory performance as measured by acute and chronic intracranial EEG
Direct recordings from the human brain have historically involved epilepsy patients undergoing invasive electroencephalography (iEEG) for surgery. However, these measurements are temporally limited and affecte...
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Article
Open AccessImmediate neurophysiological effects of transcranial electrical stimulation
Noninvasive brain stimulation techniques are used in experimental and clinical fields for their potential effects on brain network dynamics and behavior. Transcranial electrical stimulation (TES), including tr...
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Open AccessAuthor Correction: Low frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings
It has come to our attention that we did not specify whether the stimulation magnitudes we report in this Article are peak amplitudes or peak-to-peak. All references to intensity given in mA in the manuscript ...
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Article
Open AccessSuperficial Slow Rhythms Integrate Cortical Processing in Humans
The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration of activity across cortical areas is mediated anatomically by associative connections...
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Open AccessReplay of large-scale spatio-temporal patterns from waking during subsequent NREM sleep in human cortex
Animal studies support the hypothesis that in slow-wave sleep, replay of waking neocortical activity under hippocampal guidance leads to memory consolidation. However, no intracranial electrophysiological evid...
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Open AccessLow frequency transcranial electrical stimulation does not entrain sleep rhythms measured by human intracranial recordings
Transcranial electrical stimulation has widespread clinical and research applications, yet its effect on ongoing neural activity in humans is not well established. Previous reports argue that transcranial alte...
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Article
Open AccessThe genomic landscape of tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse and debilitating clinical symptoms. Patients are ...
