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Article
The killifish germline regulates longevity and somatic repair in a sex-specific manner
Classical evolutionary theories propose tradeoffs among reproduction, damage repair and lifespan. However, the specific role of the germline in sha** vertebrate aging remains largely unknown. In this study, ...
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Article
Open AccessBisection of the X chromosome disrupts the initiation of chromosome silencing during meiosis in Caenorhabditis elegans
During meiosis, gene expression is silenced in aberrantly unsynapsed chromatin and in heterogametic sex chromosomes. Initiation of sex chromosome silencing is disrupted in meiocytes with sex chromosome-autosom...
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Article
Open AccessMass spectrometry reveals the chemistry of formaldehyde cross-linking in structured proteins
Whole-cell cross-linking coupled to mass spectrometry is one of the few tools that can probe protein–protein interactions in intact cells. A very attractive reagent for this purpose is formaldehyde, a small mo...
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Article
Single-cell ChIP-seq reveals cell subpopulations defined by chromatin state
Chromatin state is analyzed for the first time in single cells, revealing new cell subpopulations.
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Article
Locus-specific editing of histone modifications at endogenous enhancers
The function of specific enhancers is studied using TAL effectors fused to a histone demethylase.
