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Article
Open AccessProteome profiling of home-sampled dried blood spots reveals proteins of SARS-CoV-2 infections
Self-sampling of dried blood spots (DBS) offers new routes to gather valuable health-related information from the general population. Yet, the utility of using deep proteome profiling from home-sampled DBS to ...
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Article
Open AccessFeasibility of using breath sampling of non-volatiles to estimate the prevalence of illicit drug use among nightlife attendees
The prevalence of drug use among nightlife attendees needs to be accurately estimated to, for example, evaluate preventive interventions. This study tested the feasibility of using a breath-sampling device to ...
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Article
Open AccessMeasurement of the alcohol biomarker phosphatidylethanol (PEth) in dried blood spots and venous blood—importance of inhibition of post-sampling formation from ethanol
Phosphatidylethanol (PEth) is a group of phospholipids formed in cell membranes following alcohol consumption by action of the enzyme phospholipase D (PLD). PEth measurement in whole blood samples is establish...
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Article
Open AccessMultianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
Serological testing is essential to curb the consequences of the COVID-19 pandemic. However, most assays are still limited to single analytes and samples collected within healthcare. Thus, we establish a multi...
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Article
Open AccessPharmacokinetics of methylphenidate and ritalinic acid in plasma correlations with exhaled breath and oral fluid in healthy volunteers
The primary aim of this study was to explore the potential of alternative sampling matrices for methylphenidate by assessing the correlations between dl-threo-methylphenidate and dl-threo-ritalinic acid concentra...
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Article
Open AccessAcute Intoxications Involving α-Pyrrolidinobutiophenone (α-PBP): Results from the Swedish STRIDA Project
Many new psychoactive substances (NPS) introduced as recreational drugs have been associated with severe intoxication and death.
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Article
Open AccessChemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users
The detection of a novel psychoactive substance, 2F-MT-45, a fluorinated analogue of the synthetic opioid MT-45, was reported in a single seized tablet. MT-45, 2F-, 3F- and 4F-MT-45 were synthesised and refere...
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Article
Open AccessAnalytically Confirmed Intoxications Involving MDMB-CHMICA from the STRIDA Project
About a decade ago, synthetic cannabinoids (SC) started to appear as recreational drugs on the new psychoactive substance (NPS) market. This report from the STRIDA project describes analytically confirmed into...
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Article
Identification of main human urinary metabolites of the designer nitrobenzodiazepines clonazolam, meclonazepam, and nifoxipam by nano-liquid chromatography-high-resolution mass spectrometry for drug testing purposes
Among the new psychoactive substances (NPS), so-called designer benzodiazepines have become of particular importance over the last 2 years, due to their increasing availability on the internet drug market. The...
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Article
Quantification of cocaine and metabolites in exhaled breath by liquid chromatography-high-resolution mass spectrometry following controlled administration of intravenous cocaine
Breath has been investigated as an alternative matrix for detecting recent cocaine intake; however, there are no controlled cocaine administration studies that investigated the drug’s disposition into breath. ...
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Article
Evaluation of coagulation assays versus LC-MS/MS for determinations of dabigatran concentrations in plasma
Dabigatran is an oral direct thrombin inhibitor for which routine laboratory monitoring is currently not recommended. However, there are situations in which measurements of the drug and its effect are desirabl...
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Article
Therapeutic drug monitoring for tomorrow
Therapeutic drug monitoring (TDM) represents an early approach to personalised medicine. It helps the clinician to individualise drug treatment and guide dosage to reach systemic drug concentrations associated...
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Article
Open AccessMeasuring substance use in the club setting: a feasibility study using biochemical markers
During the last few decades the use of club drugs (e.g., cocaine, amphetamines) has been of increased concern in nightlife settings. Traditionally, surveys have been used to estimate the use of club drugs, how...
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Article
The effects of acamprosate on alcohol-cue reactivity and alcohol priming in dependent patients: a randomized controlled trial
Acamprosate is a widely utilized, efficacious treatment for relapse prevention in alcohol-dependent patients; yet, little is known regarding its therapeutic mechanism of action.
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Article
Open AccessField-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination
Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen...
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Article
Naltrexone Attenuates the Subjective Effects of Amphetamine in Patients with Amphetamine Dependence
Amphetamine abuse and dependence is a global health concern with a collateral increase in medical and social problems. Although some of the neurobiological mechanisms underlying amphetamine dependence and its ...
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Chapter and Conference Paper
5-HTOL is a sensitive marker of recent alcohol consumption
Increased 5-hydroxytryptophol (5-HTOL) — a natural constituent of human urine — can be used as a marker of recent alcohol consumption. It is formed in the body as a metabolite of serotonin (5-hydroxytryptamine...
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Article
Natural killer cell activity and CSF monoamine metabolites in suicide attempters
The aim of this study was to investigate markers of serotonin and immune function in suicidal patients. Cytotoxic activity of natural killer cells (NK) and CD16 lymphocytes were studied in 28 suicide attempter...
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Chapter
Carbohydrate-Deficient Transferrin and 5-Hydroxytryptophol
Successful treatment of alcoholism is generally dependent on an early diagnosis. Consequently, there is a clinical need for objective and reliable markers of alcohol consumption, since valid information of alc...
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Article
Rapid hydroxylation of methtryptoline (1-methyltetrahydro-β-carboline) in rat: Identification of metabolites by chiral gas chromatography-mass spectrometry
Racemic methtryptoline (1-methyltetrahydro-β-carboline) and 5-hydroxymethtryptoline-9-carboxylic acid (6-hydroxy-1-methyltetrahydro-β-carboline-1-carboxylic acid) were administered intraperitoneally to rats and t...
