8 Result(s)

Article

Targeting the innate immune system in pediatric and adult AML

While the introduction of T cell-based immunotherapies has improved outcomes in many cancer types, the development of immunotherapies for both adult and pediatric AML has been relatively slow and limited. In a...

Alicia Perzolli, Joost B. Koedijk, C. Michel Zwaan, Olaf Heidenreich in Leukemia (2024)

Article

Combination p53 activation and BCL-x_L/BCL-2 inhibition as a therapeutic strategy in high-risk and relapsed acute lymphoblastic leukemia

Due to the rarity of TP53 mutations in acute lymphoblastic leukemia (ALL), p53 re-activation by antagonism of the p53-MDM2 interaction represents a potential therapeutic strategy for the majority of ALL. Here, we...

Hayden L. Bell, Helen J. Blair, Samantha J. Jepson Gosling, Martin Galler… in Leukemia (2024)

Article

Fusion transcripts are present in early progenitor cells in KMT2A-rearranged B-ALL

Ricky Tirtakusuma, Paul Milne, Helen J. Blair, Yuzhe Shi, Simon Bomken… in Leukemia (2024)

Article

Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia

A hallmark of acute myeloid leukaemias (AMLs) are chromosomal rearrangements that give rise to novel leukaemia-specific fusion genes. Most of these fusion genes are both initiating and driving events in AML an...

Hasan Issa, Laura E. Swart, Milad Rasouli, Minoo Ashtiani, Sirintra Nakjang… in Leukemia (2023)

Article

Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia

A common problem in the study of human malignancy is the elucidation of cancer driver mechanisms associated with recurrent deletion of regions containing multiple genes. Taking B-cell acute lymphoblastic leuka...

Paul B. Sinclair, Ruth E. Cranston, Prahlad Raninga, Joanna Cheng… in Leukemia (2023)

Article

H3K79me2/3 controls enhancer–promoter interactions and activation of the pan-cancer stem cell marker PROM1/CD133 in MLL-AF4 leukemia cells

MLL gene rearrangements (MLLr) are a common cause of aggressive, incurable acute lymphoblastic leukemias (ALL) in infants and children, most of which originate in utero. The most common MLLr produces an MLL-AF...

Laura Godfrey, Nicholas T. Crump, Sorcha O’Byrne, I-Jun Lau, Siobhan Rice… in Leukemia (2021)

Article

Optimized induction of mitochondrial apoptosis for chemotherapy-free treatment of BCR-ABL+acute lymphoblastic leukemia

BCR-ABL+acute lymphoblastic leukemia (ALL) in adults has a poor prognosis with allogeneic stem cell transplantation (SCT) considered the best curative option for suitable patients. We here characterize the cur...

Michaela Scherr, Hanna Kirchhoff, Karin Battmer, Katharina Wohlan, Chun-Wei Lee… in Leukemia (2019)

Article

siRNAs targeting the ERK2 signaling pathway and AML1/MTG8 fusion gene attenuate the differentiation, proliferation and growth arrest in t(8;21) leukemia

Salem Bashanfer, Faisal Mutee Al-Hassan, Rosline Hassan… in BMC Proceedings (2012)