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Article
The change-of-variance function for dependent data
The infinitesimal stability of the asymptotic variance is considered forM-estimators of a location parameter when the nominal sample with i.i.d. data is contaminated by a possibly dependent process. It is shown t...
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Article
Asymptotic bias and variance for a general class of varying bandwidth density estimators
We consider a general class of varying bandwidth estimators of a probability density function. The class includes the Abramson estimator, transformation kernel density estimator (TKDE), Jones transformation ke...
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Article
Open AccessMethodological study of affine transformations of gene expression data with proposed robust non-parametric multi-dimensional normalization method
Low-level processing and normalization of microarray data are most important steps in microarray analysis, which have profound impact on downstream analysis. Multiple methods have been suggested to date, but i...
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Article
Open AccessThe genetic interacting landscape of 63 candidate genes in Major Depressive Disorder: an explorative study
Genetic contributions to major depressive disorder (MDD) are thought to result from multiple genes interacting with each other. Different procedures have been proposed to detect such interactions. Which approa...
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Article
Open AccessOn the eigenvalue effective size of structured populations
A general theory is developed for the eigenvalue effective size ( \(N_{eE}\) ...
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Article
Open AccessA significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis
The genetic background to bipolar disorder (BPD) has been attributed to different genetic and genomic risk factors. In the present study we hypothesized that inherited copy number variations (CNVs) contribute ...
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Article
Open AccessThe interaction between smoking and HLA genes in multiple sclerosis: replication and refinement
Interactions between environment and genetics may contribute to multiple sclerosis (MS) development. We investigated whether the previously observed interaction between smoking and HLA genotype in the Swedish ...
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Article
Open AccessAssessment of the Global Variance Effective Size of Subdivided Populations, and Its Relation to Other Effective Sizes
The variance effective population size ( \(N_{eV}\) N ...
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Article
Open AccessEffects of subpopulation extinction on effective size (Ne) of metapopulations
Population extinction is ubiquitous in all taxa. Such extirpations can reduce intraspecific diversity, but the extent to which genetic diversity of surviving populations are affected remains largely unclear. A...
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Article
Open AccessErratum: Classification Under Partial Reject Options
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Article
Open AccessClassification Under Partial Reject Options
In many applications there is ambiguity about which (if any) of a finite number N of hypotheses that best fits an observation. It is of interest then to possibly output a whole set of categories, that is, a scena...
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Article
Open AccessThe representation, quantification, and nature of genetic information
Current genetics studies often refer to notions from information science. The purpose of this paper is to summarize and structure the different notions of information used in biology, as a step towards develop...
