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Protocol
Making NSC and Neurons from Patient-Derived Tissue Samples
The human brain and mechanisms underlying its functioning has been a field of intense research due to its complexity, inaccessibility, and the large numbers of debilitating disorders affecting this organ. Mode...
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Article
Open AccessDiscovery biology of neuropsychiatric syndromes (DBNS): a center for integrating clinical medicine and basic science
There is emerging evidence that there are shared genetic, environmental and developmental risk factors in psychiatry, that cut across traditional diagnostic boundaries. With this background, the Discovery biol...
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Article
Open AccessGenotoxic Effects of Culture Media on Human Pluripotent Stem Cells
Culture conditions play an important role in regulating the genomic integrity of Human Pluripotent Stem Cells (HPSCs). We report that HPSCs cultured in Essential 8 (E8) and mTeSR, two widely used media for fee...
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Article
Open AccessDetailed Characterization of Human Induced Pluripotent Stem Cells Manufactured for Therapeutic Applications
We have recently described manufacturing of human induced pluripotent stem cells (iPSC) master cell banks (MCB) generated by a clinically compliant process using cord blood as a starting material (Baghbaderani...
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Article
Open AccessGeneration and characterization of individual-specific induced pluripotent cells from patient-derived lymphoblastoid cell lines
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Article
Genetic Polymorphism in the Serotonin Transporter Promoter Region and Ecological Success in Macaques
A well-characterised sequence length polymorphism in the serotonin transporter promoter region (5-HTTLPR) influences individual behavioural traits and cognitive abilities in humans and rhesus macaques. Macaque...
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Article
Open AccessEvaluating epistatic interaction signals in complex traits using quantitative traits
Rheumatoid arthritis (RA) is a complex, chronic inflammatory disease implicated to have several plausible candidate loci; however, these may not account for all the genetic variations underlying RA. Common dis...
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Article
Open AccessHaplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease
Late onset Alzheimer's disease (LOAD) is a common sporadic form of the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the aetiopathology of Alzheimer's disease is that in th...
