-
Article
Structural brain abnormalities in early onset first-episode psychosis
Background. Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations.
-
Chapter and Conference Paper
SPD 502 (NS 1209), a New Selective AMPA Antagonist, Reduces the Infarct Size in Rats Following Permanent Occlusion of the Middle Cerebral Artery
Alpha-amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA)-antagonists (i.e., 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline [NBQX] and 6-(1-imidazolyl)-7-nitroquinoxaline-2,3(1H,4H)-dione [YM900]) ha...
-
Chapter
Differences between the Calculated Fraction Available for BBB Transport and the in Vitro Measured Free Fraction Could be Explained by Capillary Heterogeneity
It has earlier been shown that presence of albumin in the brain capillaries apparently enhances uptake of protein bound substances (Pardridge and Fierer, J. Neurochem. 54: 971–976,1990; Pardridge and Landaw, Am. ...
-
Article
Blood-brain barrier transport of amino acids in healthy controls and in patients with phenylketonuria
Blood-brain barrier permeability to phenylalanine and leucine in four patients with phenylketonuria and in four volunteers was measured five times by the double-indicator method at increasing plasma concentrat...
-
Article
Fourth meeting of the European Neurological Society 25–29 June 1994 Barcelona, Spain
-
Chapter and Conference Paper
Regional Cerebral Blood Flow in Acute Stroke: Comparison of Two Calcium Antagonists
Much effort has been placed in the investigation of the pathophysiological mechanisms that lead to irreversible cell damage following ischemia. Severalstudies now sem to indicate that disturbances in calcium i...
-
Article
The effect of ketanserin on cerebral blood flow and cerebrovascular CO2 reactivity in healthy volunteers
The effect of the anti-hypertensive agent ketanserin on the cerebral blood flow (CBF) and the cerebrovascular CO2 reactivity was examined in 10 healthy volunteers. Ketanserin was administered as an intravenous bo...
-
Chapter and Conference Paper
Identification of Hemodynamic Patients for EC-IC Bypass Surgery
Recurrent ischemic symptoms from a hemisphere where the internal carotid artery (ICA) is occluded are either embolic or hemodynamic. Distinguishing between these two etiologies is not possible on clinical grou...
-
Article
Effect of ketanserin on cerebral blood flow autoregulation in healthy volunteers
The effect of a clinically relevant dose of ketanserin (10 mg as a bolus followed by an infusion of 6mg/h) on cerebral blood flow (CBF) and CBF autoregulation was examined in 12 healthy volunteers. Changes in ...
-
Article
The acute effect of nimodipine on cerebral blood flow, its CO2 reactivity, and cerebral oxygen metabolism in human volunteers
The present study was undertaken in 8 healthy volunteers to examine the effect of a clinically relevant dose of nimodipine (NIM) (15 and 30 microgram/kg/h) on CBF, its CO2 reactivity, and CMRO2. Mean arterial blo...
-
Chapter and Conference Paper
Tomographic Measurements of Regional Cerebral Blood Flow by SPECT in Vascular Dementia
During the past decade, increasing awareness of the importance and high frequency of degenerative dementia disorders such as Alzheimer’s disease has accentuated the need for an accurate clinical distinction of...
-
Chapter and Conference Paper
Zerebraler Kreislauf bei Hypertonie: Risiken und therapeutische Bedeutung
Die Hypertonie ist ein Hauptrisikofaktor für zerebrovaskuläre Erkrankungen, und zu den wesentlichen Vorteilen der modernen antihypertensiven Behandlung gehört die Prävention des Schlaganfalls. Die Hypertonie v...
-
Article
Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers
The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers.
-
Article
Angiotensin converting enzyme inhibition, CBF autoregulation, and ICP in patients with normal-pressure hydrocephalus
Fourteen patients with normal pressure hydrocephalus had the autoregulation of cerebral blood flow (CBF) and intracranial pressure (ICP) investigated. In 8 of the patients the effect of Captopril on ICP and CB...
-
Chapter and Conference Paper
Brain Imaging with SPECT in Alzheimer’s Disease
Alzheimer’s disease is associated with reductions of regional cerebral blood flow and metabolism. Since the development of the 133Xe inhalation technique for tomographic measurements of regional cerebral blood fl...
-
Chapter and Conference Paper
The Acute Effect of Nimodipine on Intracranial Pressure and Cerebral Blood Flow
In acute stroke it has been shown that the calcium antagonist PY 108-068 induces a slight increase in mean cerebral blood flow (CBF) in some cases with a concomitant flow reduction in focal ischemic areas [8]....
-
Chapter and Conference Paper
CBF Decreases in Ischemic Areas After Calcium Antagonist Treatment in Acute Stroke
Over recent years, much effort has been devoted to the investigation of the pathophysiological mechanisms that lead to irreversible cell damage following ischemia. Several studies have indicated that disturban...
-
Chapter and Conference Paper
No Effect on ICP of ACE-Inhibition During Induced Hypotension
Experimental studies in rats have demonstrated that the angiotensin converting enzyme (ACE) inhibitor Captopril shifts the lower and upper limits of autoregulation of cerebral blood flow (CBF) towards lower bl...
-
Chapter and Conference Paper
The Effect of Nimodipine on ICP and CBF in the Awake Patient
In human studies it has been shown that the calcium antagonist PY 108-068 induces a considerable increase in cerebral blood flow (CBF) with a concomitant flow reduction in focal ischemic areas [9]. In experime...
-
Article
Misonidazole neuropathy A prospective study
The frequency with which polyneuropathy developed was investigated in patients with cancer of the larynx and pharynx who participated in a double-blind trial of the radiosensitizing drug misonidazole. Fourteen...
