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  1. No Access

    Article

    Complex Compounds of Rhenium-188 and Gallium-68 Radionuclides and Their Behavior in the Organism of Laboratory Animals

    This paper concerns the study of pharmacokinetic properties of rhenium-188 and gallium-68 bound to a ligand based on tetraphosphonic acid (188 Re,68 Ga-EDTMP). The pharmacokinetics of 188 Re,68 Ga-EDTMP is studie...

    V. M. Petriev, V. K. Tishchenko… in Bulletin of the Lebedev Physics Institute (2019)

  2. No Access

    Article

    Pharmacokinetics in Intact Rats of N,N,N′,N′-Ethylenediaminetetrakis-(Methylenephosphonic Acid) Labeled with Gallium-68

    Pharmacokinetic studies of the new bone-seeking radiopharmaceutical (RP) 68Ga-labeled N,N,N′,N′-ethylenediaminetetrakis(methylenephosphonic acid) (EDTMP) for PET diagnosis of bone metastases showed that 68Ga-EDTM...

    V. M. Petriev, V. K. Tishchenko, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (2017)

  3. No Access

    Article

    The Pharmacokinetics of Technetium-99m-Labeled N,N,N′,N′-Ethylenediaminetetra-Kis-(Methylenephosphonic Acid) in Intact Rats

    Pharmacokinetic studies of technetium-99m-labeled N,N,N′,N′-ethylenediaminetetra-kis-(methylenephosphonic acid) (99mTc-EDTMP) showed that this radiopharmaceutical (RP) has high in vivo stability. Studies of the b...

    V. M. Petriev, V. K. Tishchenko, K. V. Koptyaeva… in Pharmaceutical Chemistry Journal (2015)

  4. No Access

    Article

    Pharmacokinetic Study of the New Diagnostic Radiopharmaceutical 99mTc-Pentaphosphonic Acid in Rats with an Experimental Bone-Fracture Model

    The pharmacokinetic properties of a bone-seeking radiopharmaceutical based on pentaphosphonic acid labeled with technetium-99m (99mTc-PPA) were investigated. The experiments were performed in healthy rats and in ...

    V. M. Petriev, V. K. Tishchenko, O. V. Siruk… in Pharmaceutical Chemistry Journal (2014)

  5. No Access

    Article

    Pharmacokinetic Characteristics of the Radiopharmaceutical “188Re-Albumin Microspheres” After Intravenous Administration to Laboratory Animals

    Studies of the pharmacokinetics of 188Re-human serum albumin microspheres (MSA) of diameter 10 – 20 μm in intact mice showed that the maximum accumulation of activity (about 70%) 5 min at after intravenous admini...

    V. M. Petriev, O. V. Siruk, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2014)

  6. No Access

    Article

    Studies of the Pharmacokinetics of Actinium-255-Labeled Bisphosphonate in Intact Mice

    The pharmacokinetics of 225Ac-labeled hydroxyethylenediphosphoric acid monopotassium salt (225Ac-KHEDP) and 225AcCl3 were studied in intact mice after intravenous administration. The results obtained here showed ...

    V. M. Petriev, V. K. Podgorodnichenko… in Pharmaceutical Chemistry Journal (2013)

  7. No Access

    Article

    Pharmacokinetics of 188Re-labeled pentaphosphonic acid in rats with experimental bone callosity

    The influence of modeled femur callosity on the biodistribution of 188Re-labeled pentaphosphonic acid (188Re-PPA) in rats was studied. The radiopharmaceutical was injected into a tail vein 14 d after fracture. It...

    V. K. Shiryaeva, V. M. Petriev, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (2013)

  8. No Access

    Article

    Evaluation of the influence of preparation conditions on pharmacokinetics of bone-seeking radiopharmaceutical 188Re-labeled hydroxyethylidenediphosphonic acid monopotassium salt in rats

    The in vivo biodistributions of the monopotassium salt of hydroxyethylidenediphosphonate labeled with 188Re (188Re-KHEDP) were studied in rats for drug batches prepared with and without Re carrier. Also, the phar...

    V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2012)

  9. No Access

    Article

    Pharmacokinetics of a new radiopharmaceutical based on alubmin microspheres and palladium-103 and modified by heat and radiation

    The pharmacokinetics of albumin microspheres (AMS) labeled with 103Pd (103Pd-AMS) were studied in healthy mice after intramuscular injections. It was established that increasing the denaturation temperature of al...

    V. M. Petriev, V. K. Shiryaev, V. G. Skvortsov… in Pharmaceutical Chemistry Journal (2011)

  10. No Access

    Article

    Comparative analysis of pharmacokinetic characteristics of radiopharmaceuticals based on the monopotassium salt of 1-hydroxyethylidenediphosphonic acid labeled by 99mT9c and 188Re

    Investigation of pharmacokinetic characteristics of the 99mTc- and 188Re-labeled monopotassium salt of 1-hydroxyethylidenediphosphonic acid (KHEDP) in rats showed that the level of accumulated activity at 5 min a...

    V. K. Shiryaeva, V. M. Petriev, A. A. Bryukhanova… in Pharmaceutical Chemistry Journal (2011)

  11. No Access

    Article

    Distribution of sodium perrenate in intact mice

    The distribution of sodium perrenate (Na188ReO4) in the organism of intact mice has been studied. It is shown that the behavior of Na188ReO4 in the organism depends on the method of administration. In particular,...

    V. M. Petriev, O. A. Smoryzanova, V. G. Skvortsov in Pharmaceutical Chemistry Journal (2007)

  12. No Access

    Article

    Synthesis and metallothioneinogenic activity of some benzofuran derivatives

    G. M. Rott, L. I. Shevchenko, O. A. Smoryzanova… in Pharmaceutical Chemistry Journal (1998)

  13. No Access

    Article

    Arbidol as the metallothionein inductor in mice

    G. M. Rott, O. A. Smoryzanova, V. A. Romantsova… in Pharmaceutical Chemistry Journal (1997)