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  1. No Access

    Article

    Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility

    Epithelial-to-mesenchymal transition (EMT) promotes cell motility, which is important for the metastasis of malignant cells, and blocks CD95-mediated apoptotic signaling triggered by immune cells and chemother...

    V Edmond, F Dufour, G Poiroux, K Shoji, M Malleter, A Fouqué, S Tauzin… in Oncogene (2015)

  2. No Access

    Article

    Identification of a novel pro-apoptotic role of NF-κB in the regulation of TRAIL- and CD95-mediated apoptosis of glioblastoma cells

    We recently reported that nuclear factor-kappa B (NF-κB) promotes DNA damage-triggered apoptosis in glioblastoma, the most common brain tumor. In the present study, we investigated the role of NF-κB in death r...

    C Jennewein, S Karl, B Baumann, O Micheau, K-M Debatin, S Fulda in Oncogene (2012)

  3. No Access

    Article

    A mitochondrial block and expression of XIAP lead to resistance to TRAIL-induced apoptosis during progression to metastasis of a colon carcinoma

    A pair of isogenic colon carcinoma cells, SW480 and 620, was used to investigate the mechanisms of acquired tumour necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance during tumour progression...

    O Ndozangue-Touriguine, M Sebbagh, D Mérino, O Micheau, J Bertoglio, J Bréard in Oncogene (2008)

  4. No Access

    Article

    p53-Mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells

    Oxaliplatin has emerged as a major chemotherapeutic drug in the treatment of advanced colorectal cancer, yet like most conventional cancer therapeutics, its efficacy is often compromised due to p53 mutations. ...

    F Toscano, Z El Fajoui, F Gay, N Lalaoui, B Parmentier, J-A Chayvialle… in Oncogene (2008)

  5. No Access

    Article

    Controlling TRAIL-mediated caspase-3 activation

    O Micheau, D Mérino in Leukemia (2004)