10 Result(s)
within
O Melander
Medicine & Public Health
English
Medicine/Public Health, general
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Article
Open AccessMyocardial injury defined as elevated high-sensitivity cardiac troponin T is associated with higher mortality in patients seeking care at emergency departments with acute dyspnea
Elevated levels of cardiac troponin T has been observed in patients seeking care at the emergency department (ED) presenting with chest pain but without myocardial infarction (MI). The clinical importance of t...
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Article
A genetic risk score for hypertension is associated with risk of thoracic aortic aneurysm
A genetic risk score (GRS) based on 29 single nucleotide polymorpysms (SNPs) associated with high blood pressure (BP) was prospectively associated with development of hypertension, stroke and cardiovascular ev...
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Article
Association between systemic leptin and neurotensin concentration in adult individuals with and without type 2 diabetes mellitus
Leptin is an adipokine which regulates appetite and energy balance through a mechanism partially mediated by neurotensin (NT) in central nervous system. Besides acting as a neurotransmitter, NT is expressed i...
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Article
Open AccessInverse relationship between a genetic risk score of 31 BMI loci and weight change before and after reaching middle age
Genome-wide-association studies have identified numerous body mass index (BMI)-associated variants, but it is unclear how these relate to weight gain in adults at different ages.
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Article
Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study
The aim of this study was to compare novel and established anthropometrical measures in their ability to predict cardiovascular disease (CVD), and to determine whether they improve risk prediction beyond class...
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Article
Open AccessCopeptin, a marker of vasopressin, in abdominal obesity, diabetes and microalbuminuria: the prospective Malmö Diet and Cancer Study cardiovascular cohort
High plasma copeptin (copeptin), the C-terminal fragment of arginine vasopressin pro-hormone, has been associated with the metabolic syndrome (MetS), diabetes mellitus (DM) development and nephropathy. Here we...
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Article
Heritability of the ambulatory arterial stiffness index in Swedish families
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Article
Pro-opiomelanocortin gene is associated with serum leptin levels in lean but not in obese individuals
OBJECTIVE: Mutations in the pro-opiomelanocortin and melanocortin 4 receptor genes (POMC and MC4R) cause monogenic obesity, and the POMC locus (2p21) has been linked to leptin levels and body mass index (BMI). We...
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Article
Association between a variant in the 11β-hydroxysteroid dehydrogenase type 2 gene and primary hypertension
The enzyme 11β-hydroxysteroid dehydrogenase type 2 (11BHSD2) converts cortisol to cortisone in the kidney, thereby protecting the mineralocorticoid receptor from the mineralocorticoid actions of cortisol. The ...
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Article
Role of the Gly460Trp polymorphism of the α-adducin gene in primary hypertension in Scandinavians
Previous studies have suggested that the Trp460 allele of the Gly460Trp polymorphism in the α-adducin gene is associated with salt sensitivity and primary hypertension. The present study was undertaken to eval...
