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Article
Open AccessOverexpression of miR-32 in Chinese hamster ovary cells increases production of Fc-fusion protein
The demand for industrial genetically modified host cells were increased with the growth of the biopharmaceutical market. Numerous studies on improving host cell productivity have shown that altering host cell...
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Article
Recent developments in miRNA based recombinant protein expression in CHO
It is widely accepted that the growing demand for recombinant therapeutic proteins has led to the expansion of the biopharmaceutical industry and the development of strategies to increase recombinant protein p...
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Article
Anti-leishmanial and toxicity activities of some selected Iranian medicinal plants
Leishmaniasis is caused by protozoan parasites belonging to the genus Leishmania. Cutaneous leishmaniasis is the most common form of leishmaniasis in Iran. As there is not any vaccine for leishmaniasis, treatment...
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Article
Cloning and expression of human IFN-γ in Leishmania tarentolae
Increasing therapeutic applications for recombinant human interferon-gamma (rhIFN-γ), an antiviral pro-inflammatory cytokine, has broadened interest in optimizing methods for its production. We herein describe...
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Article
Cloning and expression of truncated form of tissue plasminogen activator in Leishmania tarentolae
An expression cassette containing kringle 2 and serine protease domains (K2S), tissue plasminogen activator (tPA), together with a signal sequence derived from Leishmania tarentolae and two fragments of the small...
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Article
Open AccessEvaluation of deletion of nuclease genes cluster in L. major
